Prevalência de Chlamydia Pneumoniae e Mycoplasma Pneumoniae em diferentes formas da doen？a coronariana

background: several infectious agents have been investigated since the association between atherosclerosis and infection was demonstrated; however, the results of these studies are contradictory. objective: to test the association between serum titers of anti-chlamydia and anti-mycoplasma antibodies in different forms of acute coronary syndromes (acs). methods: one hundred and twenty-six patients were divided in 4 groups: acs with st- segment elevation (32 patients), acs without st-segment elevation (30 patients), chronic coronary artery disease (30 patients) and blood donors without known coronary disease (34 patients - control group). in the two first groups, serum samples were collected at hospital admission (first 24 hours of hospitalization) and after a 6-month follow-up. in the other two groups, only a basal sample was collected. anti-chlamydia and anti-mycoplasma antibodies were measured by indirect immunofluorescence in all samples. results: significant differences were observed between the basal sample and the one measured after a 6-month follow-up in patients with myocardial infarction with st-segment elevation for chlamydia (650±115.7 versus 307±47.5, p=0.0001) as well as mycoplasma (36.5±5.0 versus 21.5±3.5, p=0.0004). the groups with acs had higher anti-chlamydia and anti-mycoplasma serum antibody levels in the basal measurement, when compared to the patients with chronic coronary disease and the control group, but the differences were not statistically significant. conclusion: the present study showed an association between the serum titers of anti-chlamydia and anti-mycoplasma antibodies in the acute phase of patients with unstable angina or myocardial infarction.