Tratamiento con hormona de crecimiento en ni？os menores de 6 a？os de edad, con talla baja, nacidos peque？os para la edad gestacional

introduction. approximately 10% of children born small for gestational age (sga) do not show spontaneous catch-up growth. objective. our objective was to assess the efficacy and safety of 2 years growth hormone treatment in children younger than 6 years of age, born sga. material and methods. fourteen patients, mean age 4.2 ± 1.1 years were treated with growth hormone at 1.0 ui/kg/wk for two years. results. growth velocity increased from a mean ± sd of 5.4 ± 1.7 cm/yr to 9.8 ± 1.50 cm/yr and 7.6 ± 1.5 cm/yr during the first year and second year, respectively (p 0.00058). serum igf-i and its binding protein bp3 increased significantly throughout treatment. basal glucose and insulin levels increased significantly during treatment, p= 0.0006 and p= 0.036, respectively, without significant changes in postprandial glucose or insulin levels. a mild change in insulin sensitivity was observed along treatment. conclusion. two years growth hormone treatment induced a significant growth acceleration in children born small for gestational age, allowing them to attain a normal height. no serious adverse events were reported.