%0 Journal Article
%T Tratamiento con hormona de crecimiento en ni£¿os menores de 6 a£¿os de edad, con talla baja, nacidos peque£¿os para la edad gestacional
%A Bergad¨¢
%A Ignacio
%A Blanco
%A Miguel
%A Keselman
%A Ana
%A Domen¨¦
%A Horacio M.
%A Bergad¨¢
%A C¨¦sar
%J Archivos argentinos de pediatr£¿-a
%D 2009
%I Sociedad Argentina de Pediatria
%X introduction. approximately 10% of children born small for gestational age (sga) do not show spontaneous catch-up growth. objective. our objective was to assess the efficacy and safety of 2 years growth hormone treatment in children younger than 6 years of age, born sga. material and methods. fourteen patients, mean age 4.2 ¡À 1.1 years were treated with growth hormone at 1.0 ui/kg/wk for two years. results. growth velocity increased from a mean ¡À sd of 5.4 ¡À 1.7 cm/yr to 9.8 ¡À 1.50 cm/yr and 7.6 ¡À 1.5 cm/yr during the first year and second year, respectively (p 0.00058). serum igf-i and its binding protein bp3 increased significantly throughout treatment. basal glucose and insulin levels increased significantly during treatment, p= 0.0006 and p= 0.036, respectively, without significant changes in postprandial glucose or insulin levels. a mild change in insulin sensitivity was observed along treatment. conclusion. two years growth hormone treatment induced a significant growth acceleration in children born small for gestational age, allowing them to attain a normal height. no serious adverse events were reported.
%K small for gestational age
%K growth hormone
%K insulin-like growth factor i
%K insulin sensitivity.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0325-00752009000500007&lng=en&nrm=iso&tlng=en