Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital

this study describes a carbapenem-resistant klebsiella pneumoniae (crkp) outbreak that occurred from october 2008-december 2010. polymerase chain reaction assays were performed to detect the blakpc gene and molecular typing was performed using pulsed-field gel electrophoresis (pfge). there were 33 crkp infections; pfge revealed five genotypes: genotype a in five (15%), b in 18 (55%), c in eight (24%) and two unique profiles. genotype b was disseminated in all hospital units and belonged to the same clone identified in 11 different hospitals in the state of s？o paulo. sixteen (48%) patients died. seven isolates (21%) were resistant to polymyxin b and 45% were resistant to tigecycline and amikacin.