Lupus eritematoso neonatal: reporte de cuatro casos

neonatal lupus erythematosus is a very rare disease, clinically characterized by skin lesions that resemble those of subacute or discoid lupus erythematosus and/or congenital heart block. generally, when patients have skin manifestations, they have no cardiac defects and vice-versa; however, in 10% of cases these manifestations may coexist. other findings may include hematologic, hepatic and neurological abnormalities. this condition is caused by the transplacental passage of maternal autoantibodies against ro (95%), la and, less frequently, u1-ribonucleoprotein (u1-rnp). the present case report describes four patients with clinical, histopathological and immunological findings compatible with neonatal lupus erythematosus, their treatment and progress.