Remiss？o de retículo-histiocitose multicêntrica com terapia combinada com infliximabe

multicentric reticulohistiocytosis is an extremely rare systemic disorder of unknown etiology. it is characterized by a severe symmetric polyarthritis which can progresses to a mutilant arthritis and papulonodular skin and mucosal lesions. the diagnostic of multicentric reticulo histiocytosis is histopathologic. approximately one-third of the adults patients have association with malignancies. there is no uniform treatment regimen for multicentric reticulohistiocytosis. we present a case of a 46-year woman with a classical clinical picture of multicentric reticulohistiocytosis. the patient received treatment with biological immunemodulators with marked results.