Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis

the results on the bioevaluation of thirty five plant-derived secondary metabolites against one sensitive and three multidrug-resistant clinical isolates of mycobacterium tuberculosis are reported. results toward the sensitive strain showed that five products gave mic values of 12.5 μg/ml: the alkaloids 6-methoxydihydrochelerytrine (2) and 6-methoxy-dihydrochelirubine (6), the flavanone pinostrobin (17), 1-hydroxy-benzoisochromanquinone (23) and 23-hydroxy-5a-lanosta-7,9(11),24-triene-3-one (33). these were followed by the peracetylstrictosidine lactam (12) and the quinone aloe-emodin (24) which displayed mics of 6.25 μg/ml. finally, liriodenine (8) was the most active (mic: 3.125 μg/ml) of all secondary metabolites. results with the multidrug-resistant clinical isolates showed that 6-methoxy-dihydrochelirubine (6) was the most active (mic: 12.5 μg/ml).