%0 Journal Article
%T Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis
%A Camacho-Corona
%A Mar¨ªa del Rayo
%A Favela-Hern¨¢ndez
%A Juan Manuel de Jes¨²s
%A Gonz¨¢lez-Santiago
%A Omar
%A Garza-Gonz¨¢lez
%A Elvira
%A Molina-Salinas
%A Gloria Mar¨ªa
%A Said-Fern¨¢ndez
%A Salvador
%A Delgado
%A Guillermo
%A Luna-Herrera
%A Julieta
%J Journal of the Mexican Chemical Society
%D 2009
%I Sociedad Qu¨ªmica de M¨¦xico
%X the results on the bioevaluation of thirty five plant-derived secondary metabolites against one sensitive and three multidrug-resistant clinical isolates of mycobacterium tuberculosis are reported. results toward the sensitive strain showed that five products gave mic values of 12.5 ¦Ìg/ml: the alkaloids 6-methoxydihydrochelerytrine (2) and 6-methoxy-dihydrochelirubine (6), the flavanone pinostrobin (17), 1-hydroxy-benzoisochromanquinone (23) and 23-hydroxy-5a-lanosta-7,9(11),24-triene-3-one (33). these were followed by the peracetylstrictosidine lactam (12) and the quinone aloe-emodin (24) which displayed mics of 6.25 ¦Ìg/ml. finally, liriodenine (8) was the most active (mic: 3.125 ¦Ìg/ml) of all secondary metabolites. results with the multidrug-resistant clinical isolates showed that 6-methoxy-dihydrochelirubine (6) was the most active (mic: 12.5 ¦Ìg/ml).
%K mycobacterium tuberculosis
%K antituberculosis activity
%K bioactive secondary metabolites
%K alkaloids
%K flavonoids
%K quinones
%K triterpenes
%K diterpenes.
%U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S1870-249X2009000200006&lng=en&nrm=iso&tlng=en