%0 Journal Article %T Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis %A Camacho-Corona %A Mar¨ªa del Rayo %A Favela-Hern¨¢ndez %A Juan Manuel de Jes¨²s %A Gonz¨¢lez-Santiago %A Omar %A Garza-Gonz¨¢lez %A Elvira %A Molina-Salinas %A Gloria Mar¨ªa %A Said-Fern¨¢ndez %A Salvador %A Delgado %A Guillermo %A Luna-Herrera %A Julieta %J Journal of the Mexican Chemical Society %D 2009 %I Sociedad Qu¨ªmica de M¨¦xico %X the results on the bioevaluation of thirty five plant-derived secondary metabolites against one sensitive and three multidrug-resistant clinical isolates of mycobacterium tuberculosis are reported. results toward the sensitive strain showed that five products gave mic values of 12.5 ¦Ìg/ml: the alkaloids 6-methoxydihydrochelerytrine (2) and 6-methoxy-dihydrochelirubine (6), the flavanone pinostrobin (17), 1-hydroxy-benzoisochromanquinone (23) and 23-hydroxy-5a-lanosta-7,9(11),24-triene-3-one (33). these were followed by the peracetylstrictosidine lactam (12) and the quinone aloe-emodin (24) which displayed mics of 6.25 ¦Ìg/ml. finally, liriodenine (8) was the most active (mic: 3.125 ¦Ìg/ml) of all secondary metabolites. results with the multidrug-resistant clinical isolates showed that 6-methoxy-dihydrochelirubine (6) was the most active (mic: 12.5 ¦Ìg/ml). %K mycobacterium tuberculosis %K antituberculosis activity %K bioactive secondary metabolites %K alkaloids %K flavonoids %K quinones %K triterpenes %K diterpenes. %U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S1870-249X2009000200006&lng=en&nrm=iso&tlng=en