Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones

the preparation of 3-substituted 1,4-benzodiazepines by benzodiazepine enolate alkylation has been explored. employing this approach, multigram quantities of benzodiazepine 1 have been prepared for animal studies to evaluate a new approach for the treatment of the autoimmune disease systemic lupus erythematosus (sle).