%0 Journal Article
%T Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
%A Kyungjin
%A Kim
%A Volkman
%A Steven K.
%A Ellman
%A Jonathan A.
%J Journal of the Brazilian Chemical Society
%D 1998
%I Sociedade Brasileira de Qu¨Şmica, SBQ
%R 10.1590/S0103-50531998000400010
%X the preparation of 3-substituted 1,4-benzodiazepines by benzodiazepine enolate alkylation has been explored. employing this approach, multigram quantities of benzodiazepine 1 have been prepared for animal studies to evaluate a new approach for the treatment of the autoimmune disease systemic lupus erythematosus (sle).
%K benzodiazepine enolate-alkylation
%K systemic lupus erythematosus.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50531998000400010&lng=en&nrm=iso&tlng=en