Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands

prostacyclin i2 inhibits platelet aggregation through specific binding to its membrane receptor. in this work, we developed 3d-qsar models for a series of aromatic heterocyclic compounds from literature using the local intersection volume descriptor. the models obtained can be applied to design new pgi2 receptor ligands with potential platelet anti-aggregating activity.