%0 Journal Article
%T Local intersection volume (LIV) descriptors: 3D-QSAR models for PGI2 receptor ligands
%A Martins
%A Rita C. A.
%A Albuquerque
%A Magaly G.
%A Alencastro
%A Ricardo B.
%J Journal of the Brazilian Chemical Society
%D 2002
%I Sociedade Brasileira de Qu¨Şmica, SBQ
%R 10.1590/S0103-50532002000600014
%X prostacyclin i2 inhibits platelet aggregation through specific binding to its membrane receptor. in this work, we developed 3d-qsar models for a series of aromatic heterocyclic compounds from literature using the local intersection volume descriptor. the models obtained can be applied to design new pgi2 receptor ligands with potential platelet anti-aggregating activity.
%K 3d-qsar
%K local intersection volume (liv)
%K prostacyclin receptor
%K platelet aggregation.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532002000600014&lng=en&nrm=iso&tlng=en