Chemical composition and antifungal activity of the essential oil of Hyptis ovalifolia Benth. (Lamiaceae)

the leaves of hyptis ovalifolia benth. (lamiaceae) were subjected to hydrodistillation and the resulting volatiles were investigated by gc/ms. the main constituent representing 60% of the essential oil was isolated by column chromatography and identified by spectroscopic methods as (r)-6-[(z)-1-heptenyl]-5,6-dihydro-2h-pyran-2-one (1). this compound showed strong in vitro activity against four dermatophyte fungi microsporum canis, microsporum gypseum, tricophyton mentagrophytes, and tricophyton rubrum (a total of 60 strains) with a minimal inhibitory concentration observed in the range of 125-7.8 mg μl-1.