Biological and structure-activity evaluation of chalcone derivatives against bacteria and fungi

the present work describes the antibacterial and antifungal activities of several chalcones obtained by a straight claisen-schmidt aldol condensation determined by the minimal inhibitory concentration against different microorganisms (gram-positive and gram-negative bacteria and fungi). solid state crystal structures of seven chalcones were determined by x-ray diffraction (xrd) analysis. chemometric studies were carried out in order to identify a potential structure-activity relationship.