%0 Journal Article
%T Biological and structure-activity evaluation of chalcone derivatives against bacteria and fungi
%A Silva
%A Wender A.
%A Andrade
%A Carlos Kleber Z.
%A Napolitano
%A Hamilton B.
%A Vencato
%A Ivo
%A Lariucci
%A Carlito
%A Castro
%A Miriam. R. C. de
%A Camargo
%A Ademir J.
%J Journal of the Brazilian Chemical Society
%D 2013
%I Sociedade Brasileira de Qu¨Şmica, SBQ
%R 10.1590/S0103-50532013000100018
%X the present work describes the antibacterial and antifungal activities of several chalcones obtained by a straight claisen-schmidt aldol condensation determined by the minimal inhibitory concentration against different microorganisms (gram-positive and gram-negative bacteria and fungi). solid state crystal structures of seven chalcones were determined by x-ray diffraction (xrd) analysis. chemometric studies were carried out in order to identify a potential structure-activity relationship.
%K chalcones
%K biological activities
%K x-ray structures
%K theoretical calculations.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532013000100018&lng=en&nrm=iso&tlng=en