Pre-surgical mood disorders associated to worse post-surgical seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis

objectives: this study aims at verifying the impact of pre-surgical pd on seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (tle-mts). methods: after previous consent, retrospective data from 115 surgically treated (corticoamygdalohyppocampectomy) tle-mts patients (65 females; 56.5%) were analyzed. psychiatric evaluations were performed through dsm-iv criteria. engel ia was established as a favorable prognosis. results: forty-five patients (41.6%) were classified as engel ia, while 47 (40.8%) presented pre-surgical pd. depression (or=5.11; p=0.004) appeared as a risk factor associated to a non-favorable seizure outcome. conclusion: in patients with refractory tle-mts, the presence of depression predicts an unfavorable outcome.