Efecto en el sangrado perioperatorio durante la resección transuretral de la próstata tras un mes de tratamiento con dutasteride

objective: evaluate the effect of dutasteride in perioperative bleeding during transurethral resection of prostate (turp). materials and methods: forty consecutive patients with criteria for turp were included. finasteride/dutasteride use, renal impairment, prostate <30cc, age <50 were excluded. patients were divided in 2 groups. group 1: 24 consecutive patients treated with dutasteride 0.5mg/day/30-days prior turp. group 2: 16 without treatment. prostatic volume, difference in hemoglobin pre/post turp, duration and amount of resected tissue were recorded. surgeon was blinded. statistical analysis: multiple linear regression, mann-whitney and student t-tests were used. results: in group 1, 33%(8) improved their lower urinary tract symptoms and skipped turp. mean hemoglobin loss difference between groups was 0.11gr/dl (ci 95% -0.55; 0.77, p=0.88). there was no statistical difference among variables. no positive or negative predictive values in the linear regression model. conclusion: dutasteride did not significantly impact the studied variables in these non randomized and small sample size settings.