Cytogenetic study of women with premature ovarian failure

etiology of premature ovarian failure (pof) is unclear in most patients. since some cases are related to x-chromosome abnormalities, cytogenetical studies were conducted in patients with pof. lymphocyte cultures from eleven patients were compared to cultures from age-matched controls. all individuals presented normal karyotypes. frequencies of aneuploid and structural chromosome aberrations did not differ between the groups. the x chromosome was more frequently involved in aneuploidy and in premature centromere division in both groups.