%0 Journal Article
%T Cytogenetic study of women with premature ovarian failure
%A Pagni
%A Denise
%A Melaragno
%A Maria Isabel
%J Genetics and Molecular Biology
%D 1998
%I Sociedade Brasileira de Gen¨¦tica
%R 10.1590/S1415-47571998000200016
%X etiology of premature ovarian failure (pof) is unclear in most patients. since some cases are related to x-chromosome abnormalities, cytogenetical studies were conducted in patients with pof. lymphocyte cultures from eleven patients were compared to cultures from age-matched controls. all individuals presented normal karyotypes. frequencies of aneuploid and structural chromosome aberrations did not differ between the groups. the x chromosome was more frequently involved in aneuploidy and in premature centromere division in both groups.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1415-47571998000200016&lng=en&nrm=iso&tlng=en