Asociación HLA clase I y leucemia en pacientes mestizos del estado Zulia, Venezuela

abstract. the human leukocyte allele (hla) class i (a, b, c) and acute lymphoid leukemia and myeloid leukemia association, was determined by polymerase chain reaction - sequence specific primers (pcr-ssp) in 60 patients and 30 healthy controls. the results were reported as allelic frequencies and haplotype. the chi-square corrected, fisher？s test, relative risk and etiologic fraction were calculated. a significant positive association was showed between hla-b*39 (rr = 16.184; p = 0.0237) and hla c*03 (rr =5.0; p = 0.0127) alleles and myeloid leukaemia. positive associations between haplotypes 2 loci: hla-a*02-c*03 (rr = 6.0; p = 0.0153), a*24-c*03 (rr = 16.184; p = 0.0237), b*40-c*03 (rr = 10.706; p = 0.0021) and haplotype 3 loci: hla-a*02-b*40-c*03 (rr = 8.11; p = 0.0102) and myeloid leukemia were found. no association was evident in acute lymphoid leukemia. no negative association with leukemias were observed