%0 Journal Article
%T Asociaci¨®n HLA clase I y leucemia en pacientes mestizos del estado Zulia, Venezuela
%A Villalobos
%A Carmen
%A Rivera
%A Sergio
%A Weir-Medina1
%A Jes¨²s
%A Manzur
%A Hassanh
%A Montiel
%A Milagros
%A Gonz¨¢lez
%A Romer
%J Investigaci¨®n Cl¨ªnica
%D 2003
%I Scientific Electronic Library Online
%X abstract. the human leukocyte allele (hla) class i (a, b, c) and acute lymphoid leukemia and myeloid leukemia association, was determined by polymerase chain reaction - sequence specific primers (pcr-ssp) in 60 patients and 30 healthy controls. the results were reported as allelic frequencies and haplotype. the chi-square corrected, fisher£¿s test, relative risk and etiologic fraction were calculated. a significant positive association was showed between hla-b*39 (rr = 16.184; p = 0.0237) and hla c*03 (rr =5.0; p = 0.0127) alleles and myeloid leukaemia. positive associations between haplotypes 2 loci: hla-a*02-c*03 (rr = 6.0; p = 0.0153), a*24-c*03 (rr = 16.184; p = 0.0237), b*40-c*03 (rr = 10.706; p = 0.0021) and haplotype 3 loci: hla-a*02-b*40-c*03 (rr = 8.11; p = 0.0102) and myeloid leukemia were found. no association was evident in acute lymphoid leukemia. no negative association with leukemias were observed
%K hla
%K leukemia
%K rr
%K pcr-ssp.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0535-51332003000400004&lng=en&nrm=iso&tlng=en