A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine

purpose: the objective of this study was to assess the cytokine serum levels of il-6 and tnf-α in rats subjected to fecal peritonitis and treated with peritoneal lavage with 0.2% ropivacaine by peritoneal lavage. methods: we subjected 16 wistar rats to laparotomy 6 hours after the induction of fecal peritonitis with autogenous stool and subsequently divided the rats randomly into 4 groups: i-control, no treatment; ii- drying of the abdominal cavity; iii- lavage of the abdominal cavity with 3 ml of 0.9% normal saline and drying; iv- lavage of the abdominal cavity with 3 ml of 0.2% ropivacaine and drying. six hours following the laparotomy, the animals underwent cardiac puncture, and 1 ml of blood was collected for cytokine assessment before the animals were euthanized. results: the lavage with ropivacaine resulted in smaller tnf-α levels compared with those observed in the other treatment groups (p <0.05). regarding il-6, the ropivacaine group showed lower cytokine levels than those observed in groups i and ii, but there was no significant difference (p> 0.05) between groups iii and iv. conclusion: peritoneal lavage with 0.2% ropivacaine was shown to reduce plasma levels of il-6 and tnf-α in the treatment of fecal peritonitis in rats.