%0 Journal Article
%T A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-¦Á) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine
%A Brocco
%A Marcos C¨¦lio
%A Paulo
%A Danilo Nagib Salom£¿o
%A Almeida
%A Carlos Eduardo David de
%A Carraretto
%A Antonio Roberto
%A Cabral
%A Sigmar Aurea
%A Silveira
%A Amanda Cardoso de Oliveira
%A Gomez
%A Renato Santiago
%A Baptista
%A Jo£¿o Flor¨ºncio de Abreu
%J Acta Cirurgica Brasileira
%D 2012
%I Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
%R 10.1590/S0102-86502012000700011
%X purpose: the objective of this study was to assess the cytokine serum levels of il-6 and tnf-¦Á in rats subjected to fecal peritonitis and treated with peritoneal lavage with 0.2% ropivacaine by peritoneal lavage. methods: we subjected 16 wistar rats to laparotomy 6 hours after the induction of fecal peritonitis with autogenous stool and subsequently divided the rats randomly into 4 groups: i-control, no treatment; ii- drying of the abdominal cavity; iii- lavage of the abdominal cavity with 3 ml of 0.9% normal saline and drying; iv- lavage of the abdominal cavity with 3 ml of 0.2% ropivacaine and drying. six hours following the laparotomy, the animals underwent cardiac puncture, and 1 ml of blood was collected for cytokine assessment before the animals were euthanized. results: the lavage with ropivacaine resulted in smaller tnf-¦Á levels compared with those observed in the other treatment groups (p <0.05). regarding il-6, the ropivacaine group showed lower cytokine levels than those observed in groups i and ii, but there was no significant difference (p> 0.05) between groups iii and iv. conclusion: peritoneal lavage with 0.2% ropivacaine was shown to reduce plasma levels of il-6 and tnf-¦Á in the treatment of fecal peritonitis in rats.
%K peritonitis
%K anesthesia
%K sepsis
%K il-6
%K tnf-¦Á.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502012000700011&lng=en&nrm=iso&tlng=en