Background: The increasing prevalence of metabolic disorders highlights the need for dietary strategies that regulate postprandial glycemic responses and enhance satiety. Low-glycemic index (GI) foods enriched with whole grains and functional fibers can attenuate glucose spikes and support appetite regulation. This study evaluated the glycemic index and satiety effects of fiber-rich, vitamin- and mineral-enriched cookies, Britannia NutriChoice Advanced1 Ragi Cookies and Britannia NutriChoice Advanced1 Oats Cookies, in healthy Indian adults. Methods: A randomized, crossover, single-center study was conducted in 20 healthy Indian adults. Each participant consumed five treatments in random order: three administrations of the reference and one administration each of the two test cookies. The dosage was adjusted so that both reference and test products provided 25 g of available carbohydrates. Capillary blood glucose was recorded at baseline (mean of ？5 and 0 minutes) and at 15, 30, 45, 60, 90, and 120 minutes post-consumption to calculate the incremental area under the curve (IAUC). The entire study of GI assessment was conducted according to the ISO 26642:2010 protocol. Satiety was assessed using a validated 7-point Visual Analogue Scale (VAS) for up to 240 minutes. Results: Both test cookies produced significantly lower IAUC values than the reference glucose (p < 0.0001). The GI values were 48.03 ± 4.39 for NutriChoice Advanced Ragi Cookies and 50.23 ± 4.53 for NutriChoice Advanced Oats Cookies, classifying both as low-GI foods. Both cookies elicited sustained fullness responses, in contrast to the minimal and transient satiety response with glucose. At 15 minutes post-consumption, 94.74% of participants reported fullness after consuming Ragi Cookies and 100% after consuming Oats Cookies; this sensation of fullness remained for up to 60 minutes for both cookies. Satiety persisted up to 90 minutes in 68.42% of participants following Ragi Cookies consumption and 84.21% following Oats Cookies consumption, with residual satiety up to 180 minutes. Conclusion: NutriChoice Advanced Ragi and Oats Cookies demonstrated low GI values, attenuated postprandial glycemic responses, and promoted sustained satiety in healthy adults. These findings support these cookies as functional and metabolically supportive snacking options suitable for individuals who practice mindful snacking and those prioritizing their glycemic control.
References
[1]
American Diabetes Association (2014) Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 37, S81-S90.
[2]
American Diabetes Association (2023) Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2023. Diabetes Care, 46, S19-S40.
[3]
Hu, F.B. (2011) Globalization of Diabetes: The Role of Diet, Lifestyle, and Genes. Diabetes Care, 34, 1249-1257. https://doi.org/10.2337/dc11-0442
[4]
Goyal, R., Singhal, M. and Jialal, I. (2025) Type 2 Diabetes. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK513253/
[5]
International Diabetes Federation (2021) IDF Diabetes Atlas. 10th Edition, International Diabetes Federation.
[6]
Anjana, R.M., Unnikrishnan, R., Deepa, M., Pradeepa, R., Tandon, N., Das, A.K., et al. (2023) Metabolic Non-Communicable Disease Health Report of India: The ICMR-INDIAB National Cross-Sectional Study (ICMR-INDIAB-17). The Lancet Diabetes & Endocrinology, 11, 474-489. https://doi.org/10.1016/s2213-8587(23)00119-5
[7]
Magliano, D.J., Boyko, E.J. and IDF Diabetes Atlas 10th Edition Scientific Committee (2021) Top 10 Countries for Adults with Diabetes. https://www.ncbi.nlm.nih.gov/books/NBK581940/table/ch3.t4/
[8]
Zheng, Y., Ley, S.H. and Hu, F.B. (2018) Global Aetiology and Epidemiology of Type 2 Diabetes Mellitus and Its Complications. Nature Reviews Endocrinology, 14, 88-98. https://doi.org/10.1038/nrendo.2017.151
[9]
Hill-Briggs, F., Adler, N.E., Berkowitz, S.A., Chin, M.H., Gary-Webb, T.L., Navas-Acien, A., et al. (2021) Social Determinants of Health and Diabetes: A Scientific Review. Diabetes Care, 44, 258-279. https://doi.org/10.2337/dci20-0053
[10]
Venn, B.J. and Green, T.J. (2007) Glycemic Index and Glycemic Load: Measurement Issues and Their Effect on Diet-Disease Relationships. European Journal of Clinical Nutrition, 61, S122-S131. https://doi.org/10.1038/sj.ejcn.1602942
[11]
Ludwig, D.S., Majzoub, J.A., Al-Zahrani, A., Dallal, G.E., Blanco, I. and Roberts, S.B. (1999) High Glycemic Index Foods, Overeating, and Obesity. Pediatrics, 103, e26. https://doi.org/10.1542/peds.103.3.e26
[12]
Bhoite, R., Immadisetti, P., Kalpana, N., Padmavathi, S., Gayathri, R., Sudha, V., et al. (2024) Evaluation of the Glycemic Index of Protein-and Fiber-Rich Biscuits Designed for Healthy Snacking. Journal of Food and Nutrition Sciences, 12, 287-293. https://doi.org/10.11648/j.jfns.20241206.15
[13]
Olagunju, A.I., Arigbede, T.I., Oyeleye, I.S., et al. (2024) High-Protein, Low Glycemic Index Snack from an Optimized Blend of Three Whole Grains Elicits a Low Glycemic Response in Diabetic Human Subjects. Food Production, Processing and Nutrition, 6, Article No. 32.
[14]
Jacob, J., Krishnan, V., Antony, C., Bhavyasri, M., Aruna, C., Mishra, K., et al. (2024) The Nutrition and Therapeutic Potential of Millets: An Updated Narrative Review. Frontiers in Nutrition, 11, Article 1346869. https://doi.org/10.3389/fnut.2024.1346869
[15]
Ahamed, V.P.A., Joshi, A., Mudey, A., Choudhari, S., Raut, J. and Ahmed, S. (2024) Unlocking the Potential: Millets and Their Impact on Diabetes Management. Cureus, 16, e59283. https://doi.org/10.7759/cureus.59283
[16]
Rai, A., Saroj, R. and Ramachandra, K. (2024) Finger Millet: A Comprehensive Review. International Journal of Ayurvedic Medicine, 15, 103-107.
[17]
Andhare, M., Shirole, A. and Gambhir, S. (2025) Ragi (Eleusine coracana): A Review of Its Nutritional Composition and Health Benefits. Indian Journal of Nutrition, 12, Article 318.
[18]
Paudel, D., Dhungana, B., Caffe, M. and Krishnan, P. (2021) A Review of Health-Beneficial Properties of Oats. Foods, 10, Article 2591. https://doi.org/10.3390/foods10112591
[19]
Zhang, K., Dong, R., Hu, X., Ren, C. and Li, Y. (2021) Oat-Based Foods: Chemical Constituents, Glycemic Index, and the Effect of Processing. Foods, 10, Article 1304. https://doi.org/10.3390/foods10061304
[20]
Ngaha, W.D., Tchabo, W., Matsinkou, R.S., Nyame, L.K. and Fombang, E.N. (2023) Formulation of Low Glycaemic Index Biscuits Suitable for Diabetics from Unripe Banana, Okra, and Stevia Leaves/Jujube Fruit. Food Production, Processing and Nutrition, 5, Article No. 32. https://doi.org/10.1186/s43014-023-00148-x
[21]
International Organization for Standardization (2010) ISO 26642: 2010—Food Products—Determination of the Glycaemic Index (GI) and Recommendations for Food Classification. ISO.
[22]
Jenkins, D.J., Wolever, T.M., Taylor, R.H., Barker, H., Fielden, H., Baldwin, J.M., et al. (1981) Glycemic Index of Foods: A Physiological Basis for Carbohydrate Exchange. The American Journal of Clinical Nutrition, 34, 362-366. https://doi.org/10.1093/ajcn/34.3.362
[23]
Dong, J.Y., Zhang, L., Zhang, Y.H. and Qin, L.Q. (2011) Dietary Glycaemic Index and Glycaemic Load in Relation to the Risk of Type 2 Diabetes: A Meta-Analysis. British Journal of Nutrition, 106, 1649-1654.
[24]
Eliza, E., Sumarman, S., Yunianto, A.E. and Fadly, D. (2022) Nutrition Education Regarding the Glycemic Index on the Knowledge of Patients with Diabetes Mellitus. Open Access Macedonian Journal of Medical Sciences, 10, 1174-1177. https://doi.org/10.3889/oamjms.2022.9986
[25]
Augustin, L.S.A., Kendall, C.W.C., Jenkins, D.J.A., Willett, W.C., Astrup, A., Barclay, A.W., et al. (2015) Glycemic Index, Glycemic Load and Glycemic Response: An International Scientific Consensus Summit from the ICQC. Nutrition, Metabolism and Cardiovascular Diseases, 25, 795-815. https://doi.org/10.1016/j.numecd.2015.05.005
[26]
Chiavaroli, L., Lee, D., Ahmed, A., et al. (2021) Effects of Low Glycaemic Index or Load Diets on Glycaemic Control and Cardiometabolic Risk: Systematic Review and Meta-Analysis. British Medical Journal, 374, n1651.
[27]
Seal, C.J., Courtin, C.M., Venema, K. and de Vries, J. (2021) Health Benefits of Whole Grain: Effects on Dietary Carbohydrate Quality, the Gut Microbiome, and Consequences of Processing. Comprehensive Reviews in Food Science and Food Safety, 20, 2742-2768. https://doi.org/10.1111/1541-4337.12728
[28]
Pino, J.L., Mujica, V. and Arredondo, M. (2021) Effect of Dietary Supplementation with Oat β-Glucan in Type 2 Diabetes: Randomized Controlled Trial. Journal of Functional Foods, 77, Article 104311.
[29]
Khadilkar, A., Bhoite, R., Bhatte, S., Satyavrat, V., Katare, S., Sadananda, M.P., Sanghavi, A. and Unnisa, R. (2025) Enhancing Innate Immunity through Gummies Enriched with a Prebiotic Fiber (β-Glucan) and Micronutrients: Immuno Shield Trial, Proof of Concept, Single Arm, Open Label Trial in Children Aged 3-6 Years. Food and Nutrition Sciences, 16, 611-622. https://doi.org/10.4236/fns.2025.166035
[30]
Singh, V., Lee, G., Son, H., Amani, S., Baunthiyal, M. and Shin, J. (2022) Anti-Diabetic Prospects of Dietary Bio-Actives of Millets and the Significance of the Gut Microbiota: A Case of Finger Millet. Frontiers in Nutrition, 9, Article 1056445. https://doi.org/10.3389/fnut.2022.1056445
Shehzad, A., Rabail, R., Munir, S., Jan, H., Fernández-Lázaro, D. and Aadil, R.M. (2023) Impact of Oats on Appetite Hormones and Body Weight Management: A Review. Current Nutrition Reports, 12, 66-82. https://doi.org/10.1007/s13668-023-00454-3
[33]
Contreras-Bolívar, V., García-Fontana, B., García-Fontana, C. and Muñoz-Torres, M. (2021) Relationship between Vitamin D and Insulin Resistance. Nutrients, 13, Article 3491.
[34]
Aguilera-Méndez, A., Boone-Villa, D., Nieto-Aguilar, R., Villafaña-Rauda, S., Molina, A.S. and Sobrevilla, J.V. (2022) Role of Vitamins in the Metabolic Syndrome and Cardiovascular Disease. European Journal of Physiology, 474, 117-140. https://doi.org/10.1007/s00424-021-02619-x
[35]
Hua, Y., Clark, S., Ren, J. and Sreejayan, N. (2012) Molecular Mechanisms of Chromium in Alleviating Insulin Resistance. The Journal of Nutritional Biochemistry, 23, 313-319. https://doi.org/10.1016/j.jnutbio.2011.11.001
[36]
Cruz, K.J.C., de Oliveira, A.R.S., Morais, J.B.S., Severo, J.S., Mendes, P.M.V., de Sousa Melo, S.R., etal. (2018) Zinc and Insulin Resistance: Biochemical and Molecular Aspects. Biological Trace Element Research, 186, 407-412. https://doi.org/10.1007/s12011-018-1308-z
[37]
Patel, I., Patel, K., Pinto, S. and Patel, S. (2016) Ragi: A Powerhouse of Nutrients. Research and Reviews: Journal of Dairy Science and Technology, 5, 36-47.
[38]
Almaski, A., Coe, S., Lightowler, H., Clegg, M.E. and Thondre, P.S. (2023) Finger Millet-Based Muffin Decreases Insulin Response in Individuals with Prediabetes in a Randomised Controlled Trial. British Journal of Nutrition, 129, 650-659. https://doi.org/10.1017/s0007114522001623
[39]
Erbakan, A.N., Arslan Bahadir, M., Gonen, O. and Kaya, F.N. (2024) Mindful Eating and Current Glycemic Control in Patients with Type 2 Diabetes. Cureus, 16, e57198. https://doi.org/10.7759/cureus.57198
