To analyze the effects of plasmalogen-containing scallop-derived lipids on lifespan, health span, and neuroendocrine status, we assessed the effects of these lipids on the lifespan, health (motility), aging (lipofuscin accumulation), oxidative stress resistance, and neurotransmitter (dopamine, serotonin, and oxytocin) levels of Caenorhabditis elegans. The administration of scallop-derived lipids extended the lifespan of C. elegans and suppressed the age-related reduction in movement. Additionally, its oxidative stress resistance increased, despite the higher intracellular levels of reactive oxygen species. Moreover, scallop-derived lipids reduced the accumulation of lipofuscin, which is an aging marker in nematodes, and increased the levels of neurotransmitters (dopamine, serotonin, and oxytocin). Furthermore, the gene expression levels of pmk-1 (p38 mitogen-activated protein kinase 1) and daf-16 (dauer formation-16) were increased. These results indicate that plasmalogen-containing scallop-derived lipids may extend the lifespan and health span of C. elegans, and affect its neurotransmitter secretion.
References
[1]
Braverman, N.E. and Moser, A.B. (2012) Functions of Plasmalogen Lipids in Health and Disease. Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease, 1822, 1442-1452. https://doi.org/10.1016/j.bbadis.2012.05.008
[2]
Farooqui, A.A. and Horrocks, L.A. (2001) Book Review: Plasmalogens: Workhorse Lipids of Membranes in Normal and Injured Neurons and Glia. The Neuroscientist, 7, 232-245. https://doi.org/10.1177/107385840100700308
[3]
Maeba, R., Maeda, T., Kinoshita, M., Takao, K., Takenaka, H., Kusano, J., et al. (2007) Plasmalogens in Human Serum Positively Correlate with High-Density Lipoprotein and Decrease with Aging. Journal of Atherosclerosis and Thrombosis, 14, 12-18. https://doi.org/10.5551/jat.14.12
[4]
Han, X., Holtzman, D.M. and McKeel, D.W. (2001) Plasmalogen Deficiency in Early Alzheimer’s Disease Subjects and in Animal Models: Molecular Characterization Using Electrospray Ionization Mass Spectrometry. Journal of Neurochemistry, 77, 1168-1180. https://doi.org/10.1046/j.1471-4159.2001.00332.x
[5]
Mawatari, S., Fukata, M., Arita, T., Maruyama, T., Kono, S. and Fujino, T. (2022) Decreases of Ethanolamine Plasmalogen and Phosphatidylcholine in Erythrocyte Are a Common Phenomenon in Alzheimer’s, Parkinson’s, and Coronary Artery Diseases. Brain Research Bulletin, 189, 5-10. https://doi.org/10.1016/j.brainresbull.2022.08.009
[6]
Yamashita, S., Kiko, T., Fujiwara, H., Hashimoto, M., Nakagawa, K., Kinoshita, M., et al. (2016) Alterations in the Levels of Amyloid-β, Phospholipid Hydroperoxide, and Plasmalogen in the Blood of Patients with Alzheimer’s Disease: Possible Interactions between Amyloid-β and These Lipids. Journal of Alzheimer’s Disease, 50, 527-537. https://doi.org/10.3233/jad-150640
[7]
Abe, Y., Honsho, M., Nakanishi, H., Taguchi, R. and Fujiki, Y. (2014) Very-Long-chain Polyunsaturated Fatty Acids Accumulate in Phosphatidylcholine of Fibroblasts from Patients with Zellweger Syndrome and Acyl-CoA Oxidase1 Deficiency. Biochimica et Biophysica Acta (BBA)—Molecular and Cell Biology of Lipids, 1841, 610-619. https://doi.org/10.1016/j.bbalip.2014.01.001
[8]
Hossain, M.S., Ifuku, M., Take, S., Kawamura, J., Miake, K. and Katafuchi, T. (2013) Plasmalogens Rescue Neuronal Cell Death through an Activation of AKT and ERK Survival Signaling. PLOS ONE, 8, e83508. https://doi.org/10.1371/journal.pone.0083508
[9]
Ifuku, M., Katafuchi, T., Mawatari, S., Noda, M., Miake, K., Sugiyama, M., et al. (2012) Anti-Inflammatory/Anti-Amyloidogenic Effects of Plasmalogens in Lipopolysaccharide-Induced Neuroinflammation in Adult Mice. Journal of Neuroinflammation, 9, Article No. 197. https://doi.org/10.1186/1742-2094-9-197
[10]
Yamashita, S., Hashimoto, M., Haque, A.M., Nakagawa, K., Kinoshita, M., Shido, O., et al. (2017) Oral Administration of Ethanolamine Glycerophospholipid Containing a High Level of Plasmalogen Improves Memory Impairment in Amyloid β-Infused Rats. Lipids, 52, 575-585. https://doi.org/10.1007/s11745-017-4260-3
[11]
Fujino, T., Yamada, T., Asada, T., Tsuboi, Y., Wakana, C., Mawatari, S., et al. (2017) Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer’s Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. EBioMedicine, 17, 199-205. https://doi.org/10.1016/j.ebiom.2017.02.012
[12]
Obo, T., Obo, M., Fukuchi, M., Sasuga, Y., Fujino, T. and Kono, S. (2023) Orally Administered Plasmalogens Alleviate Psycho-Behavioral Parameters in Patients with Depressive Disorder: An Observational Study. MJCR, 1-14.
[13]
Lewis, J.E. and Fravel, L.A. (2023) The Effects of HSOP on Cognition, Depression, and Activities of Daily Living in Older Adults with Cognitive Issues. Integrative Medicine: A Clinician’s Journal, 21, 16-20.
[14]
Sugawara, T., Furuhashi, T., Shibata, K., Abe, M., Kikuchi, K., Arai, M., et al. (2019) Fermented Product of Rice with Lactobacillus kefiranofaciens Induces Anti-Aging Effects and Heat Stress Tolerance in Nematodes via Daf-16. Bioscience, Biotechnology, and Biochemistry, 83, 1484-1489. https://doi.org/10.1080/09168451.2019.1606696
[15]
Sugawara, T. and Sakamoto, K. (2020) Quercetin Enhances Motility in Aged and Heat-Stressed Caenorhabditis elegans Nematodes by Modulating Both HSF-1 Activity, and Insulin-Like and p38-MAPK Signalling. PLOS ONE, 15, e0238528. https://doi.org/10.1371/journal.pone.0238528
[16]
Yan, Z., Feng, J., Fienberg, A.A. and Greengard, P. (1999) D2 Dopamine Receptors Induce Mitogen-Activated Protein Kinase and Camp Response Element-Binding Protein Phosphorylation in Neurons. Proceedings of the National Academy of Sciences of the United States of America, 96, 11607-11612. https://doi.org/10.1073/pnas.96.20.11607
[17]
Jiang, Y., Gaur, U., Cao, Z., Hou, S. and Zheng, W. (2022) Dopamine D1-and D2-Like Receptors Oppositely Regulate Lifespan via a Dietary Restriction Mechanism in Caenorhabditis elegans. BMC Biology, 20, Article No. 71. https://doi.org/10.1186/s12915-022-01272-9
[18]
Murakami, H. and Murakami, S. (2007) Serotonin Receptors Antagonistically Modulate Caenorhabditis elegans Longevity. Aging Cell, 6, 483-488. https://doi.org/10.1111/j.1474-9726.2007.00303.x
[19]
Somuah-Asante, S. and Sakamoto, K. (2022) Stress Buffering and Longevity Effects of Amber Extract on Caenorhabditis elegans (C. Elegans). Molecules, 27, Article 3858. https://doi.org/10.3390/molecules27123858
[20]
Yasuda, K. and Sakamoto, K. (2019) Oxytocin Promotes Heat Stress Tolerance via Insulin Signals in Caenorhabditis elegans. Bioscience, Biotechnology, and Biochemistry, 83, 1858-1866. https://doi.org/10.1080/09168451.2019.1630253
[21]
Speranza, L., di Porzio, U., Viggiano, D., de Donato, A. and Volpicelli, F. (2021) Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control. Cells, 10, Article 735. https://doi.org/10.3390/cells10040735
[22]
Frouni, I., Kwan, C., Belliveau, S. and Huot, P. (2022) Cognition and Serotonin in Parkinson’s Disease. Progress in Brain Research, 269, 373-403. https://doi.org/10.1016/bs.pbr.2022.01.013
[23]
Mitre, M., Minder, J., Morina, E.X., Chao, M.V. and Froemke, R.C. (2017) Oxytocin Modulation of Neural Circuits. In: Hurlemann, R. and Grinevich, V., Eds., Behavioral Pharmacology of Neuropeptides: Oxytocin, Springer, 31-53. https://doi.org/10.1007/7854_2017_7
