Background: The degradation of dynamic vision due to aging and visual display terminal (VDT) work is considered to significantly affect the quality of daily life. The intake of green tea containing epigallocatechin gallate (EGCG) has been reported to improve dynamic vision and is expected to prevent its decline. However, no clinical study has ever been conducted to evaluate green tea’s effect on dynamic vision in humans. Therefore, we aimed to evaluate the effects of a supplement containing green tea (Camellia sinensis O. Ktze.) extract rich in EGCG on dynamic vision in humans. Methods: A randomized, double-blind, placebo-controlled, parallel-group study was conducted to evaluate the effects of Camellia sinensis O. Ktze. extract on dynamic vision in healthy participants. Forty healthy men and women were enrolled and randomly divided into an active group that consumed a supplement containing Camellia sinensis O. Ktze. extract (100 mg epigallocatechin gallate/day) for 6 weeks and a placebo group that consumed a supplement without the extract for the same period. The primary outcome was kinetic visual acuity (KVA). The secondary outcomes were the results of a questionnaire survey and a cognitive function test. Results: The active group showed a statistically significant improvement in KVA, compared to the placebo group (P < 0.05). In addition, no adverse events attributable to the studied supplements were observed during the study period. Conclusions: These findings indicate that consuming supplements containing Camellia sinensis O. Ktze. extract may positively impact dynamic vision.
References
[1]
Japan Safe Driving Center (2000) Untensha no Shintaiteki Kino no Keinen Henka ni Kansuru Chosa Kenkyu Hokokusho. (In Japanese) https://www.jsdc.or.jp/Portals/0/pdf/library/research/h10_3.pdf
[2]
Suzumura, A. (1974) Variation of Visual Perception of Spatial Objects and Development of Perceptual Aptitude. Journal of Japanese Ophthalmological Society, 75, 22-54.
[3]
Lie, I. and Watten, R.G. (1994) VDT Work, Oculomotor Strain, and Subjective Complaints: An Experimental and Clinical Study. Ergonomics, 37, 1419-1433. https://doi.org/10.1080/00140139408964919
[4]
Tatsukawa, Y., Nanba, T., Suematsu, O., Setoguchi, N. and Tabuchi, A. (2005) Immediate Effects of Horizontal/Vertical Eye Movements Playing Personal Computer Games on Visual Function. Kawasaki Medical Welfare Journal, 14, 313-321. https://doi.org/10.15112/00012748
[5]
Honaker, J.A. and Shepard, N.T. (2011) Use of the Dynamic Visual Acuity Test as a Screener for Community-Dwelling Older Adults Who Fall. Journal of Vestibular Research, 21, 267-276. https://doi.org/10.3233/ves-2011-0427
[6]
Pan, S., Nie, Q., Tai, H., Song, X., Tong, Y., Zhang, L., et al. (2022) Tea and Tea Drinking: China’s Outstanding Contributions to the Mankind. Chinese Medicine, 17, Article No. 27. https://doi.org/10.1186/s13020-022-00571-1
[7]
Sugita, Y. and Furukawa, T. (2022) Effect of Green Tea and Tea Catechin on the Visual Motion Processing for Optokinetic Responses in Mice. Neuroscience, 501, 42-51. https://doi.org/10.1016/j.neuroscience.2022.08.013
[8]
Sugita, Y. (2025) Tea Catechins and Visual Motion Processing. In: Preedy, V.R. and Patel, V.B., Eds., Tea in Health and Disease Prevention, Elsevier, 771-781. https://doi.org/10.1016/b978-0-443-14158-4.00075-0
[9]
Cabrera, C., Artacho, R. and Giménez, R. (2006) Beneficial Effects of Green Tea—A Review. Journal of the American College of Nutrition, 25, 79-99. https://doi.org/10.1080/07315724.2006.10719518
[10]
Chu, K.O., Chan, K.P., Wang, C.C., Chu, C.Y., Li, W.Y., Choy, K.W., et al. (2010) Green Tea Catechins and Their Oxidative Protection in the Rat Eye. Journal of Agricultural and Food Chemistry, 58, 1523-1534. https://doi.org/10.1021/jf9032602
[11]
Costa, B.L.D.S.A.D., Fawcett, R., Li, G., Safa, R. and Osborne, N.N. (2008) Orally Administered Epigallocatechin Gallate Attenuates Light-Induced Photoreceptor Damage. Brain Research Bulletin, 76, 412-423. https://doi.org/10.1016/j.brainresbull.2008.01.022
[12]
Falsini, B., Marangoni, D., Salgarello, T., Stifano, G., Montrone, L., Di Landro, S., et al. (2009) Effect of Epigallocatechin-Gallate on Inner Retinal Function in Ocular Hypertension and Glaucoma: A Short-Term Study by Pattern Electroretinogram. Graefe’sArchive for Clinical and Experimental Ophthalmology, 247, 1223-1233. https://doi.org/10.1007/s00417-009-1064-z
[13]
Cheong, A., Siong, K.H., Tsang, W. and Chan, H.L.H. (2013) Relationship between Dynamic Vision and Balance in Older Adults. Investigative Ophthalmology & Visu-al Science, 54, 1526.
[14]
Tyler, S.L., Maltby, J., Paterson, K.B. and Hutchinson, C.V. (2022) Reduced Vision-Related Quality of Life in Dementia: A Preliminary Report. Journal of Alzheimer’s Disease, 87, 239-246. https://doi.org/10.3233/jad-215435
[15]
Kaido, M., Fukui, M., Kawashima, M., Negishi, K. and Tsubota, K. (2020) Relationship between Visual Function and Cognitive Function in the Elderly: A Cross-Sectional Observational Study. PLOS ONE, 15, e0233381. https://doi.org/10.1371/journal.pone.0233381
[16]
Yoshida, K., Sakai, O., Honda, T., Kikuya, T., Takeda, R., Sawabe, A., et al. (2023) Effects of Astaxanthin, Lutein, and Zeaxanthin on Eye-Hand Coordination and Smooth-Pursuit Eye Movement after Visual Display Terminal Operation in Healthy Subjects: A Randomized, Double-Blind Placebo-Controlled Intergroup Trial. Nutrients, 15, Article 1459. https://doi.org/10.3390/nu15061459
[17]
Haga, T. (2014) Iyakuhin Kaihatsu no Tame no Tokei Kaiseki Dai 2-Bu Jikken Keikakuho. Scientist Press, 144-145.
[18]
Tanaka, J. (1989) Fatigue Caused by Visual Display Terminal Work: An Experimental Investigation. Hiroshima Journal of Medical Sciences, 38, 69-74.
[19]
Nakamura, M., Tanaka, M. and Kudou, D. (2005) Effects of Aging and Regular Exercise on the Visual Functions. Juntendo Medical Journal, 51, 153-159. https://doi.org/10.14789/pjmj.51.153
[20]
Kang, Q. and Yang, C. (2020) Oxidative Stress and Diabetic Retinopathy: Molecular Mechanisms, Pathogenetic Role and Therapeutic Implications. Redox Biology, 37, Article ID: 101799. https://doi.org/10.1016/j.redox.2020.101799
[21]
Daniel, A., Premilovac, D., Foa, L., Feng, Z., Shah, K., Zhang, Q., et al. (2021) Novel Short-Chain Quinones to Treat Vision Loss in a Rat Model of Diabetic Retinopathy. International Journal of Molecular Sciences, 22, Article 1016. https://doi.org/10.3390/ijms22031016
[22]
Ide, K., Yamada, H., Takuma, N., Park, M., Wakamiya, N., Nakase, J., et al. (2014) Green Tea Consumption Affects Cognitive Dysfunction in the Elderly: A Pilot Study. Nutrients, 6, 4032-4042. https://doi.org/10.3390/nu6104032
[23]
Baba, Y., Takihara, T., Kaneko, T. and Sagesaka, Y. (2019) Effects of a Daily Intake of Matcha on Cognitive Function in Middle-Aged and Older Subjects—A Place-Bo-Controlled, Randomized, Double-Blind, Parallel-Group Study. Japanese Pharmacology & Therapeutics, 47, 1689-1702.
