Objective: To explore the efficacy and safety of knee joint injection of TNF-α antagonist (Yisaipu injection) in patients with rheumatoid arthritis under ultrasound “visualization” guidance. Methods: A total of 240 patients with rheumatoid arthritis from Jingzhou First People’s Hospital were selected as research subjects between May 2024 and May 2025, randomly divided into a control group (120 patients) and an intra-articular injection group (120 patients). The control group received treatment with prednisone tablets 10mg qd + methotrexate 10mg qw; the intra-articular injection group received an additional 25mg TNF-α antagonist (Yisaipu injection) via knee joint puncture under ultrasound guidance. Data on knee joint MSUS ultrasound scores, erythrocyte sedimentation rate, C-reactive protein, and DAS28 score were collected at 0, 3, and 6 months post-treatment for observation of therapeutic effects. Results: After treatment, the knee joint MSUS ultrasound scores, serological indicators, and DAS28 scores in the intra-articular injection group showed significant improvement compared to the control group, with no significant adverse reactions observed. Conclusion: Under ultrasound “visualization” guidance, knee joint injection of TNF-α antagonist in patients with rheumatoid arthritis has significant efficacy and high safety, and musculoskeletal ultrasound assessment can provide effective evidence.
References
[1]
Smolen, J.S., Aletaha, D., Barton, A., Burmester, G.R., Emery, P., Firestein, G.S., et al. (2018) Rheumatoid Arthritis. Nature Reviews Disease Primers, 4, Article No. 18001. https://doi.org/10.1038/nrdp.2018.1
[2]
Jiang, N., Tian, X.P. and Zeng, X.F. (2025) Interpretation of the 2024 Chinese Rheumatoid Arthritis Diagnosis and Treatment Guidelines. Chinese Journal of Medical Sciences, 16, 28-34.
[3]
Jin, Y., Desai, R.J., Liu, J., Choi, N. and Kim, S.C. (2017) Factors Associated with Initial or Subsequent Choice of Biologic Disease-Modifying Antirheumatic Drugs for Treatment of Rheumatoid Arthritis. Arthritis Research & Therapy, 19, Article No. 159. https://doi.org/10.1186/s13075-017-1366-1
[4]
Guo, L.L., Wang, W.P., Hao, L.L., et al. (2021) The Clinical Value of Muscle Bone Ultra-Sound in Assessing the Disease Activity of Rheumatoid Arthritis Patients. Chinese Journal of Laboratory Medicine, 25, 217-220.
[5]
Liang, D.F., Huang, F., Zhang, JL., et al. (2020) A Randomized, Single-Blind, Parallel, Controlled Clinical Study on the Treatment of Inflammatory Knee Arthritis with a Single Intra-Articular Injection of Etanercept. Chinese Journal of Internal Medicine, 49, 930-934.
[6]
Ohrndorf, S., Werner, S.G., Finzel, S. and Backhaus, M. (2013) Musculoskeletal Ultrasound and Other Imaging Modalities in Rheumatoid Arthritis. Current Opinion in Rheumatology, 25, 367-374. https://doi.org/10.1097/bor.0b013e32835fad45
[7]
Lethaby, A., Lopez-Olivo, M.A. Maxwell, L., et al. (2023) Recombinant Human Tumor Necrosis Factor-Fc for the Treatment of Rheumatoid Arthritis. Cochrane Database of Systematic Reviews, 5, CD00452.
[8]
Wang, Q.W. (2021) The Value of Musculoskeletal Ultrasound in the Assessment of Rheumatoid Arthritis and Clinical Disease Activity Monitoring in Knee Joints. Practical Hospital Clinical Journal, 18, 24-27.
[9]
Liu, Y.Y. (2024) The Value of Musculoskeletal Ultrasound in Assessing Disease Activity in Patients with Rheumatoid Arthritis. Radiological Research and Medical Applications, 8, 50-52, 55.
[10]
Ohrndorf, S., Werner, S.G., Finzel, S. and Backhaus, M. (2013) Musculoskeletal Ultrasound and Other Imaging Modalities in Rheumatoid Arthritis. Current Opinion in Rheumatology, 25, 367-374. https://doi.org/10.1097/bor.0b013e32835fad45
[11]
Bliddal, H., Terslev, L., Qvistgaard, E., Konig, M., Holm, C.C., Rogind, H., et al. (2006) A Randomized, Controlled Study of a Single Intra-Articular Injection of Etanercept or Glucocorticosteroids in Patients with Rheumatoid Arthritis. Scandinavian Journal of Rheumatology, 35, 341-345. https://doi.org/10.1080/03009740600844530
[12]
Zhang, X., Zhu, J.J., Yuan, D.J., et al. (2023) The Diagnostic Value of Color Doppler Musculoskeletal Ultrasound and Magnetic Resonance Imaging (MRI) in the Diagnosis of Knee Osteoarthritis in Rheumatoid Arthritis. Chinese Journal of CT and MRI, 21, 169-171.
