%0 Journal Article
%T Clinical Efficacy and Safety Evaluation of TNF-<i>&#945;</i> Antagonist Ultrasound-Guided Knee Injection for Rheumatoid Arthritis
%A Yameng Yang
%A Min Wang
%J Journal of Biosciences and Medicines
%P 221-230
%@ 2327-509X
%D 2025
%I Scientific Research Publishing
%R 10.4236/jbm.2025.135017
%X <b>Objective:</b> To explore the efficacy and safety of knee joint injection of TNF-<i>&#945;</i> antagonist (Yisaipu injection) in patients with rheumatoid arthritis under ultrasound &#8220;visualization&#8221; guidance. <b>Methods:</b> A total of 240 patients with rheumatoid arthritis from Jingzhou First People&#8217;s Hospital were selected as research subjects between May 2024 and May 2025, randomly divided into a control group (120 patients) and an intra-articular injection group (120 patients). The control group received treatment with prednisone tablets 10mg qd + methotrexate 10mg qw; the intra-articular injection group received an additional 25mg TNF-<i>&#945;</i> antagonist (Yisaipu injection) via knee joint puncture under ultrasound guidance. Data on knee joint MSUS ultrasound scores, erythrocyte sedimentation rate, C-reactive protein, and DAS28 score were collected at 0, 3, and 6 months post-treatment for observation of therapeutic effects. <b>Results:</b> After treatment, the knee joint MSUS ultrasound scores, serological indicators, and DAS28 scores in the intra-articular injection group showed significant improvement compared to the control group, with no significant adverse reactions observed. <b>Conclusion:</b> Under ultrasound &#8220;visualization&#8221; guidance, knee joint injection of TNF-<i>&#945;</i> antagonist in patients with rheumatoid arthritis has significant efficacy and high safety, and musculoskeletal ultrasound assessment can provide effective evidence.
%K Musculoskeletal Ultrasound
%K Ultrasound Guidance
%K Rheumatoid Arthritis
%K Knee Joint Cavity Injection
%K TNF-<i>&#945
%K </i> Antagonist
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=142789