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呼吸衰竭的相关研究
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Abstract:
呼吸衰竭是一种以肺通气和(或)换气功能严重障碍为特征的临床综合征，作为临床常见危重症，呼吸衰竭具有并发症多样、病死率高等特点。因此，深入探讨其病理生理机制及临床特征具有重要的临床意义。本综述将从病理机制、临床分型、多系统损害、治疗策略阐述呼吸衰竭，旨在为临床实践提供理论依据，并推动个体化治疗策略的发展。
Respiratory failure is a clinical syndrome characterized by severe impairment of pulmonary ventilation and/or gas exchange. As a common critical illness, respiratory failure is characterized by various complications and high morbidity and mortality. Therefore, in-depth exploration of its pathophysiological mechanisms and clinical features is of great clinical significance. In this review, respiratory failure will be described in terms of pathomechanisms, clinical typing, multi-system damage, and therapeutic strategies, with the aim of providing a theoretical basis for clinical practice and promoting the development of individualized therapeutic strategies.
| [1] | Zhou, P., Guo, Q., Wang, F., Zhou, L., Hu, H. and Deng, Z. (2024) Nonlinear Relationship between Platelet Count and 30-Day In-Hospital Mortality in ICU Acute Respiratory Failure Patients: A Multicenter Retrospective Cohort Study. European Journal of Medical Research, 29, Article No. 312. https://doi.org/10.1186/s40001-024-01909-1 |
| [2] | Stefan, M.S., Shieh, M., Pekow, P.S., Rothberg, M.B., Steingrub, J.S., Lagu, T., et al. (2013) Epidemiology and Outcomes of Acute Respiratory Failure in the United States, 2001 to 2009: A National Survey. Journal of Hospital Medicine, 8, 76-82. https://doi.org/10.1002/jhm.2004 |
| [3] | See, K.C. (2022) Approach to Acute Respiratory Failure for Frontline Clinicians. Singapore Medical Journal, 63, 740-745. https://doi.org/10.4103/singaporemedj.smj-2022-002 |
| [4] | Petersson, J. and Glenny, R.W. (2014) Gas Exchange and Ventilation-Perfusion Relationships in the Lung. European Respiratory Journal, 44, 1023-1041. https://doi.org/10.1183/09031936.00037014 |
| [5] | Weibel, E.R. (2016) Lung Morphometry: The Link between Structure and Function. Cell and Tissue Research, 367, 413-426. https://doi.org/10.1007/s00441-016-2541-4 |
| [6] | Gunning, K.E. (2003) Pathophysiology of Respiratory Failure and Indications for Respiratory Support. Surgery (Oxford), 21, 72-76. https://doi.org/10.1383/surg.21.3.72.14672 |
| [7] | Tobin, C.E. (1966) Arteriovenous Shunts in the Peropheral Pulmonary Circulation in the Human Lung. Thorax, 21, 197-204. https://doi.org/10.1136/thx.21.3.197 |
| [8] | McMullan, D.M., Hanley, F.L., Cohen, G.A., Portman, M.A. and Riemer, R.K. (2004) Pulmonary Arteriovenous Shunting in the Normal Fetal Lung. Journal of the American College of Cardiology, 44, 1497-1500. https://doi.org/10.1016/j.jacc.2004.06.064 |
| [9] | Lee, H.N. and Hyun, D. (2022) Pulmonary Arteriovenous Malformation and Its Vascular Mimickers. Korean Journal of Radiology, 23, 202-217. https://doi.org/10.3348/kjr.2021.0417 |
| [10] | Williams, A.J. (1998) ABC of Oxygen: Assessing and Interpreting Arterial Blood Gases and Acid-Base Balance. BMJ, 317, 1213-1216. https://doi.org/10.1136/bmj.317.7167.1213 |
| [11] | Weibel, E. (2009) What Makes a Good Lung? Swiss Medical Weekly, 139, 375-386. https://doi.org/10.4414/smw.2009.12270 |
| [12] | O’Driscoll, B.R., Rudenski, A., Turkington, P.M. and Howard, L.S. (2011) An Audit of Hypoxaemia, Hyperoxaemia, Hypercapnia and Acidosis in Blood Gas Specimens. European Respiratory Journal, 39, 219-221. https://doi.org/10.1183/09031936.00042711 |
| [13] | Sbaih, N., Hawthorne, K., Lutes, J. and Cavallazzi, R. (2021) Nutrition Therapy in Non-Intubated Patients with Acute Respiratory Failure. Current Nutrition Reports, 10, 307-316. https://doi.org/10.1007/s13668-021-00367-z |
| [14] | Cree, B.A.C., Niu, J., Hoi, K.K., Zhao, C., Caganap, S.D., Henry, R.G., et al. (2017) Clemastine Rescues Myelination Defects and Promotes Functional Recovery in Hypoxic Brain Injury. Brain, 141, 85-98. https://doi.org/10.1093/brain/awx312 |
| [15] | Gunn, A.J. and Bennet, L. (2016) Timing Still Key to Treating Hypoxic Ischaemic Brain Injury. The Lancet Neurology, 15, 126-127. https://doi.org/10.1016/s1474-4422(15)00386-5 |
| [16] | Rossi, V.A., Stradling, J.R. and Kohler, M. (2012) Effects of Obstructive Sleep Apnoea on Heart Rhythm. European Respiratory Journal, 41, 1439-1451. https://doi.org/10.1183/09031936.00128412 |
| [17] | Hesp, A.C., Schaub, J.A., Prasad, P.V., Vallon, V., Laverman, G.D., Bjornstad, P., et al. (2020) The Role of Renal Hypoxia in the Pathogenesis of Diabetic Kidney Disease: A Promising Target for Newer Renoprotective Agents Including SGLT2 Inhibitors? Kidney International, 98, 579-589. https://doi.org/10.1016/j.kint.2020.02.041 |
| [18] | Ziaka, M. and Exadaktylos, A. (2024) Exploring the Lung-Gut Direction of the Gut-Lung Axis in Patients with ARDS. Critical Care, 28, Article No. 179. https://doi.org/10.1186/s13054-024-04966-4 |
| [19] | Frat, J., Thille, A.W., Mercat, A., Girault, C., Ragot, S., Perbet, S., et al. (2015) High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure. New England Journal of Medicine, 372, 2185-2196. https://doi.org/10.1056/nejmoa1503326 |
| [20] | Grieco, D.L., Maggiore, S.M., Roca, O., Spinelli, E., Patel, B.K., Thille, A.W., et al. (2021) Non-Invasive Ventilatory Support and High-Flow Nasal Oxygen as First-Line Treatment of Acute Hypoxemic Respiratory Failure and Ards. Intensive Care Medicine, 47, 851-866. https://doi.org/10.1007/s00134-021-06459-2 |
| [21] | Grieco, D.L., Munshi, L. and Piquilloud, L. (2023) Personalized Noninvasive Respiratory Support for Acute Hypoxemic Respiratory Failure. Intensive Care Medicine, 49, 840-843. https://doi.org/10.1007/s00134-023-07048-1 |
| [22] | Frat, J., Thille, A.W., Mercat, A., Girault, C., Ragot, S., Perbet, S., et al. (2015) High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure. New England Journal of Medicine, 372, 2185-2196. https://doi.org/10.1056/nejmoa1503326 |
| [23] | Telias, I., Brochard, L.J., Gattarello, S., Wunsch, H., Junhasavasdikul, D., Bosma, K.J., et al. (2022) The Physiological Underpinnings of Life-Saving Respiratory Support. Intensive Care Medicine, 48, 1274-1286. https://doi.org/10.1007/s00134-022-06749-3 |
| [24] | Pearson, S.D., Koyner, J.L. and Patel, B.K. (2022) Management of Respiratory Failure: Ventilator Management 101 and Noninvasive Ventilation. Clinical Journal of the American Society of Nephrology, 17, 572-580. https://doi.org/10.2215/cjn.13091021 |
| [25] | Bauer, P.R., Gajic, O., Nanchal, R., Kashyap, R., Martin-Loeches, I., Sakr, Y., et al. (2017) Association between Timing of Intubation and Outcome in Critically Ill Patients: A Secondary Analysis of the ICON Audit. Journal of Critical Care, 42, 1-5. https://doi.org/10.1016/j.jcrc.2017.06.010 |
| [26] | Mellado-Artigas, R., Borrat, X., Ferreyro, B.L., Yarnell, C., Hao, S., Wanis, K.N., et al. (2024) Effect of Immediate Initiation of Invasive Ventilation on Mortality in Acute Hypoxemic Respiratory Failure: A Target Trial Emulation. Critical Care, 28, Article No. 157. https://doi.org/10.1186/s13054-024-04926-y |
| [27] | Marini, J.J. and Gattinoni, L. (2024) The Ventilator of the Future: Key Principles and Unmet Needs. Critical Care, 28, Article No. 284. https://doi.org/10.1186/s13054-024-05060-5 |
| [28] | Liu, C., Wu, K., Sun, T., Chen, B., Yi, Y., Ren, R., et al. (2022) Effect of Invasive Mechanical Ventilation on the Diversity of the Pulmonary Microbiota. Critical Care, 26, Article No. 252. https://doi.org/10.1186/s13054-022-04126-6 |
| [29] | Gibilaro, J.M., Keating, C., Benvenuto, L., Kramer, A., Privorotskiy, A., Zheng, Y., et al. (2022) Survival in Cystic Fibrosis after Acute Respiratory Failure Supported by Extracorporeal Membrane Oxygenation and/or Invasive Mechanical Ventilation. Journal of Cystic Fibrosis, 21, 669-674. https://doi.org/10.1016/j.jcf.2021.08.016 |
| [30] | Ventetuolo, C.E. and Muratore, C.S. (2014) Extracorporeal Life Support in Critically Ill Adults. American Journal of Respiratory and Critical Care Medicine, 190, 497-508. https://doi.org/10.1164/rccm.201404-0736ci |
| [31] | Tipograf, Y., Salna, M., Minko, E., Grogan, E.L., Agerstrand, C., Sonett, J., et al. (2019) Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation. The Annals of Thoracic Surgery, 107, 1456-1463. https://doi.org/10.1016/j.athoracsur.2019.01.032 |
| [32] | Lo Coco, V., Lorusso, R., Raffa, G.M., Malvindi, P.G., Pilato, M., Martucci, G., et al. (2018) Clinical Complications during Veno-Arterial Extracorporeal Membrane Oxigenation in Post-Cardiotomy and Non Post-Cardiotomy Shock: Still the Achille’s Heel. Journal of Thoracic Disease, 10, 6993-7004. https://doi.org/10.21037/jtd.2018.11.103 |
