|
|
妊娠期糖尿病巨大儿胎盘超微结构改变
|
Abstract:
随着我国糖尿病人数的不断增加，以及随着生育政策的变化，晚育女性的数量有所上升，妊娠期糖尿病(gestational diabetes mellitus, GDM)的人数不断增加，对孕妇和胎儿健康都有极大危害。GDM作为巨大儿发生的高危因素，GDM导致巨大儿的发生率增加，对母儿均有影响。胎盘介于胎儿与母体之间，是胎儿的关键附属物，负责物质交换、防御、合成及免疫等多种功能。研究妊娠期糖尿病巨大儿的胎盘超微结构能够完善关于妊娠期糖尿病巨大儿的相关理论。本文将对妊娠期糖尿病巨大儿的胎盘超微结构进行综述，以期为该领域的研究提供理论依据，并为临床干预提供参考。
With the increasing number of diabetic patients in China and the change of fertility policy, the number of women with late childbearing has increased, and the number of gestational diabetes mellitus (GDM) is increasing, which is very harmful to the health of pregnant women and fetuses. GDM is a high-risk factor for macrosomia, and GDM leads to an increase in the incidence of macrosomia, which has an impact on both mother and child. The placenta is a key appendage of the fetus between the fetus and the mother, responsible for material exchange, defense, synthesis and immunity. Studying the placental ultrastructure of gestational macrosomia in gestational diabetes macrosomia infants can improve the relevant theories about gestational diabetes macrosomia infants. This article will review the ultrastructural changes in the placenta of macrosomic infants due to gestational diabetes mellitus, aiming to provide a theoretical basis for research in this field and offer reference for clinical interventions.
| [1] | (2022) Guideline of Diagnosis and Treatment of Hyperglycemia in Pregnancy (2022) [Part One]. Chinese Journal of Obstetrics and Gynecology, 57, 3-12. |
| [2] | American Diabetes Association (2020) 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes—2021. Diabetes Care, 44, S200-S210. https://doi.org/10.2337/dc21-s014 |
| [3] | Hod, M., Kapur, A., Sacks, D.A., Hadar, E., Agarwal, M., Di Renzo, G.C., et al. (2015) The International Federation of Gynecology and Obstetrics (FIGO) Initiative on Gestational Diabetes Mellitus: A Pragmatic Guide for Diagnosis, Management, and Care. International Journal of Gynecology & Obstetrics, 131, S173-S211. |
| [4] | 窦海达, 张小凤, 柏如海, 等. 巨大儿发生状况及其影响因素分析[J]. 西安交通大学学报(医学版), 2017, 38(6): 888-891, 897. |
| [5] | Kolahi, K.S., Valent, A.M. and Thornburg, K.L. (2017) Cytotrophoblast, Not Syncytiotrophoblast, Dominates Glycolysis and Oxidative Phosphorylation in Human Term Placenta. Scientific Reports, 7, Article No. 42941. https://doi.org/10.1038/srep42941 |
| [6] | 王晓彤, 何小颖, 高平明, 等. 妊娠期糖尿病与子代新生儿期代谢物水平的关系[J]. 中华围产医学杂志, 2021, 24(11): 828-833. |
| [7] | 陈雨菡, 石小鹏, 马善波, 等. 黄芪中毛蕊异黄酮的脑保护作用研究进展[J]. 中国急救医学, 2021, 41(11): 1004-1008. |
| [8] | 赵静, 张丽英, 康红霞. 基于自噬途径探讨黄芪甲苷抑制糖尿病肾病系膜细胞NLRP3炎症小体活化通路及机制[J]. 中医药导报, 2021, 27(9): 41-46. |
| [9] | Stanirowski, P.J., Lipa, M., Bomba-Opoń, D. and Wielgoś, M. (2021) Expression of Placental Glucose Transporter Proteins in Pregnancies Complicated by Fetal Growth Disorders. Advances in Protein Chemistry and Structural Biology, 123, 95-131. https://doi.org/10.1016/bs.apcsb.2019.12.003 |
| [10] | Ning, J., Huai, J., Wang, S., Yan, J., Su, R., Zhang, M., et al. (2023) METTL3 Regulates Glucose Transporter Expression in Placenta Exposed to Hyperglycemia through the mTOR Signaling Pathway. Chinese Medical Journal, 137, 1563-1575. https://doi.org/10.1097/cm9.0000000000002840 |
| [11] | Clarson, C., Tevaarwerk, G.J.M., Harding, P.G.R., Chance, G.W. and Daria Haust, M. (1989) Placental Weight in Diabetic Pregnancies. Placenta, 10, 275-281. https://doi.org/10.1016/0143-4004(89)90028-3 |
| [12] | Taricco, E., Radaelli, T., Nobile de Santis, M.S. and Cetin, I. (2003) Foetal and Placental Weights in Relation to Maternal Characteristics in Gestational Diabetes. Placenta, 24, 343-347. https://doi.org/10.1053/plac.2002.0913 |
| [13] | 申彩霞, 刘晓宁. 妊娠糖尿病胎盘绒毛和微绒毛的形态学及超微结构改变[J]. 中华病理学杂志, 2011, 40(12): 856-859. |
| [14] | Calderon, I.M.P., Damasceno, D.C., Amorin, R.L., Costa, R.A.A., Brasil, M.A.M. and Rudge, M.V.C. (2007) Morphometric Study of Placental Villi and Vessels in Women with Mild Hyperglycemia or Gestational or Overt Diabetes. Diabetes Research and Clinical Practice, 78, 65-71. https://doi.org/10.1016/j.diabres.2007.01.023 |
| [15] | 闫洪超, 薛加强, 董红燕, 等. 妊娠期糖尿病患者胎盘超微结构的研究[J]. 徐州医学院学报, 2006, 26(3): 248-250. |
| [16] | 赵娜, 米阳, 宋妙妙. 妊娠期糖尿病并发巨大儿产妇胎盘超微结构及相关参数变化[J]. 山东医药, 2020, 60(32): 5-8. |
| [17] | 韩云, 郑艳莉, 吴爱民, 等. 妊娠期糖尿病患者胎盘超微结构改变及其影响因素[J]. 山东医药, 2016, 56(35): 59-61. |
| [18] | 申彩霞, 靳钰, 张战红. 妊娠期糖尿病胎盘微绒毛形态计量学改变与围产儿并发症关系的探讨[J]. 现代妇产科进展, 2007, 16(6): 413-416. |
| [19] | 徐丽珍, 符玉亭. 妊娠期糖尿病胎盘微绒毛体视学初探[J]. 实用医学杂志, 2000, 16(10): 828-829. |
| [20] | 米阳, 郭娜, 黄谱, 等. 妊娠期糖尿病胎盘超微结构与胎儿生长异常的关系[J]. 中国实用妇科与产科杂志, 2010, 26(12): 936-939. |
| [21] | Meng, Q., Shao, L., Luo, X., Mu, Y., Xu, W., Gao, C., et al. (2015) Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus. Obstetrics and Gynecology International, 2015, Article ID: 283124. https://doi.org/10.1155/2015/283124 |
| [22] | Yang, W.-C.V., Su, T.-H., Yang, Y.-C., Chang, S.-C., Chen, C.-Y. and Chen, C.-P. (2005) Altered Perlecan Expression in Placental Development and Gestational Diabetes Mellitus. Placenta, 26, 780-788. https://doi.org/10.1016/j.placenta.2004.11.002 |
| [23] | 张硕, 宋薇薇. 妊娠期糖尿病产妇分娩巨大儿相关因素分析[J]. 中国生育健康杂志, 2016, 27(3): 215-218. |
| [24] | 龙俊青, 国林青, 覃钰芹, 等. 巨大儿发生危险因素的病例对照研究及预测模型[J]. 中国妇幼保健, 2020, 35(16): 2999-3004. |
| [25] | Fraenkel, M., Shafat, T., Cahn, A., Erez, O., Novack, V. and Tsur, A. (2018) Low Thyroid‐Stimulating Hormone and Its Persistence Beyond the First Trimester of Pregnancy. International Journal of Gynecology & Obstetrics, 142, 270-276. https://doi.org/10.1002/ijgo.12540 |
| [26] | 李冰飞, 朱大伟, 李力. 巨大儿的研究进展[J]. 中国妇产科临床杂志, 2020, 21(6): 664-666. |
