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两种氟磷苯基化合物的合成及其抑菌活性研究
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Abstract:
为设计并合成新的含磷氟键的化合物，并研究其性质，以二苯基氯化膦，苯基二氯化膦为反应物，通过简单的卤素交换反应合成两种化合物PhP(O)F2、Ph2P(O)F，并通过单晶X-射线衍射仪，1H、31P、19F NMR对其结构进行表征。同时对其进行抑菌活性筛选，发现二者对于两种革兰氏菌(大肠杆菌、金黄色葡萄球菌)均具有良好的抑菌活性，并得到了最小抑菌浓度。
To design and synthesize new phosphorus-fluorine-containing compounds, and to study their properties, two compounds, PhP(O)F2 and Ph2P(O)F, were synthesized from diphenylphosphine chloride and phenylphosphorus dichloride through a simple halogen exchange reaction. Their structures were characterized by single-crystal X-ray diffraction, 1H, 31P, and 19F NMR spectroscopies. Additionally, their antibacterial activity was screened against two Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), revealing that both compounds exhibited good antibacterial activity with minimum inhibitory concentrations determined.
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