%0 Journal Article
%T 两种氟磷苯基化合物的合成及其抑菌活性研究<br>Syntheses and Antibacterial Activity Study of Two Fluorophosphonylphenyl Compounds
%A 梁晴雯
%A 陈冲
%A 潘松
%A 张千峰
%J Hans Journal of Chemical Engineering and Technology
%P 72-79
%@ 2161-8852
%D 2025
%I Hans Publishing
%R 10.12677/hjcet.2025.152007
%X 为设计并合成新的含磷氟键的化合物&#65292;并研究其性质&#65292;以二苯基氯化膦&#65292;苯基二氯化膦为反应物&#65292;通过简单的卤素交换反应合成两种化合物PhP(O)F<sub>2</sub>、Ph<sub>2</sub>P(O)F&#65292;并通过单晶X-射线衍射仪&#65292;<sup>1</sup>H、<sup>31</sup>P、<sup>19</sup>F NMR对其结构进行表征。同时对其进行抑菌活性筛选&#65292;发现二者对于两种革兰氏菌(大肠杆菌、金黄色葡萄球菌)均具有良好的抑菌活性&#65292;并得到了最小抑菌浓度。<br>To design and synthesize new phosphorus-fluorine-containing compounds, and to study their properties, two compounds, PhP(O)F<sub>2</sub> and Ph<sub>2</sub>P(O)F, were synthesized from diphenylphosphine chloride and phenylphosphorus dichloride through a simple halogen exchange reaction. Their structures were characterized by single-crystal X-ray diffraction, <sup>1</sup>H, <sup>31</sup>P, and <sup>19</sup>F NMR spectroscopies. Additionally, their antibacterial activity was screened against two Gram-positive bacteria (<i>Staphylococcus aureus</i>) and Gram-negative bacteria (<i>Escherichia coli</i>), revealing that both compounds exhibited good antibacterial activity with minimum inhibitory concentrations determined.
%K 磷氟化合物&#65292
%K 磷酰基&#65292
%K 抑菌活性&#65292
%K 晶体结构<br>Phosphorus Fluoride Compounds
%K Phosphoryl Group
%K Antibacterial Activity
%K Crystal Structure
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=109890