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进展性肺纤维化病例报告1例及文献复习
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Abstract:
进展性肺纤维化(progressive pulmonary fibrosis, PPF)是一类表现为肺纤维化程度进行性加重、肺生理功能下降导致患者早期死亡的非特发性肺纤维化(idiopathic pulmonary fibrosis, IPF)的疾病的统称，其病情进展迅速，治疗难度大，预后差。结缔组织相关间质性肺病(interstitial lung disease associated with connective tissue disease, CTD-ILD)是PPF重要的分型。侵袭性肺曲霉菌病(Invasive pulmonary aspergillosis, IPA)具有高致死率的特点，其发病呈逐年增长趋势。本文报道1例进展性肺纤维化合并侵袭性肺曲霉菌感染典型病例，总结其诊治要点，以相关文献复习。
PPF includes non-idiopathic pulmonary fibrosis that aggravates progressively pulmonary fibrosis and lung function causing early death and presents rapid progress, difficult treatment, and poor prognosis. CTD-ILD is important for this. IPA presents high fatality rate and incidence increase. It reports a case of PPF combined with IPA, summarizes diagnosis and treatment, and reviews relevant literature.
| [1] | Raghu, G., Remy-Jardin, M., Richeldi, L., et al. (2022) Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. American Journal of Respiratory and Critical Care Medicine, 205, e18-e47. |
| [2] | Rajan, S.K., Cottin, V., Dhar, R., Danoff, S., Flaherty, K.R., Brown, K.K., et al. (2022) Progressive Pulmonary Fibrosis: An Expert Group Consensus Statement. European Respiratory Journal, 61, Article ID: 2103187. https://doi.org/10.1183/13993003.03187-2021 |
| [3] | 邹如意, 蔡后荣. 进展性纤维化性间质性肺疾病: 新概念与新机遇[J]. 中华结核和呼吸杂志, 2021, 44(6): 559-561. |
| [4] | Kim, K., Lee, J. and Jo, Y.S. (2023) Factors for Progressive Pulmonary Fibrosis in Connective Tissue Disease-Related Interstitial Lung Disease. Therapeutic Advances in Respiratory Disease, 17, 1-11. https://doi.org/10.1177/17534666231212301 |
| [5] | Spagnolo, P., Distler, O., Ryerson, C.J., Tzouvelekis, A., Lee, J.S., Bonella, F., et al. (2021) Mechanisms of Progressive Fibrosis in Connective Tissue Disease (CTD)-Associated Interstitial Lung Diseases (ILDs). Annals of the Rheumatic Diseases, 80, 143-150. https://doi.org/10.1136/annrheumdis-2020-217230 |
| [6] | 孙宇新, 黄慧. 尼达尼布治疗进展性纤维化间质性肺疾病INBUILD试验的亚组分析[J]. 中华结核和呼吸杂志, 2020(6): 552. |
| [7] | Kurosaki, F., Bando, M., Nakayama, M., Mato, N., Nakaya, T., Yamasawa, H., et al. (2014) Clinical Features of Pulmonary Aspergillosis Associated with Interstitial Pneumonia. Internal Medicine, 53, 1299-1306. https://doi.org/10.2169/internalmedicine.53.1578 |
| [8] | Ullmann, A.J., Aguado, J.M., Arikan-Akdagli, S., Denning, D.W., Groll, A.H., Lagrou, K., et al. (2018) Diagnosis and Management of Aspergillus Diseases: Executive Summary of the 2017 ESCMID-ECMM-ERS Guideline. Clinical Microbiology and Infection, 24, e1-e38. https://doi.org/10.1016/j.cmi.2018.01.002 |
| [9] | 丁百兴, 王明贵. 艾沙康唑和伏立康唑[J]. 中国感染与化疗杂志, 2017, 17(1): 51. |
| [10] | Chen, X., Lin, S., Jin, Q., Zhang, L., Jiang, W., Lu, X., et al. (2024) Prevalence, Risk Factors, and Mortality of Invasive Pulmonary Aspergillosis in Patients with Anti-MDA5+ Dermatomyositis: A Retrospective Study in China. Journal of Inflammation Research, 17, 3247-3257. https://doi.org/10.2147/jir.s460702 |
| [11] | Sokolove, J. (2021) Lung Inflammation, NETosis, and the Pulmonary Initiation of Anti-Citrullinated Protein Antibody Response: What Came First, the Chicken or the Egg? Arthritis & Rheumatology, 74, 10-12. https://doi.org/10.1002/art.41947 |
| [12] | Okamoto, Y., Devoe, S., Seto, N., Minarchick, V., Wilson, T., Rothfuss, H.M., et al. (2021) Association of Sputum Neutrophil Extracellular Trap Subsets with Iga Anti-Citrullinated Protein Antibodies in Subjects at Risk for Rheumatoid Arthritis. Arthritis & Rheumatology, 74, 38-48. https://doi.org/10.1002/art.41948 |
| [13] | Chang, S.H., Park, Y., McDermott, G.C., Paudel, M.L., Hayashi, K., Ha, Y., et al. (2025) Serum Biomarkers of Pulmonary Damage and Risk for Progression of Rheumatoid Arthritis-Associated Interstitial Lung Disease. The Journal of Rheumatology, 52. https://doi.org/10.3899/jrheum.2024-0713 |
| [14] | Luppi, F., Sebastiani, M., Salvarani, C., Bendstrup, E. and Manfredi, A. (2021) Acute Exacerbation of Interstitial Lung Disease Associated with Rheumatic Disease. Nature Reviews Rheumatology, 18, 85-96. https://doi.org/10.1038/s41584-021-00721-z |
