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植入式左心辅助装置后右心衰竭临床研究进展
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Abstract:
终末期心力衰竭是难治性心血管危重疾病，尽管有许多新药物及新技术的出现并应用于临床，但终末期心力衰竭依然具有较高的死亡风险。除药物治疗外，越来越多的证据表明左心辅助装置是终末期心力衰竭患者的重要治疗手段。但左心辅助装置后右心衰竭仍是一大挑战，左心辅助装置手术成功与否，右心室功能是关键之一，本文主要根据近几年的文献报道，归纳整理了左心辅助装置后右心衰竭的研究进展。
End-stage heart failure is a critical cardiovascular disease that is difficult to treat. Although many new drugs and technologies have been developed and applied to clinical practice, end-stage heart failure has a high risk of death. In addition to medication, there is growing evidence that left heart assistive devices are an important treatment for patients with end-stage heart failure. However, right heart failure after left heart assist device is still a big challenge, and right ventricular function is one of the key factors for the success of left heart assist device operation. This paper summarized the research progress of right heart failure after left heart assist device based on recent literature.
| [1] | 中华医学会心血管病学分会, 中国医师协会心血管内科医师分会, 中国医师协会心力衰竭专业委员会, 中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2024 [J]. 中华心血管病杂志, 2024, 52(3): 235-275. |
| [2] | 王华, 刘宇佳, 杨杰孚. 心力衰竭流行病学[J]. 临床心血管病杂志, 2023, 39(4): 243-247. |
| [3] | Frigerio, M. (2021) Left Ventricular Assist Device. Heart Failure Clinics, 17, 619-634. https://doi.org/10.1016/j.hfc.2021.05.007 |
| [4] | Rose, E.A., Gelijns, A.C., Moskowitz, A.J., Heitjan, D.F., Stevenson, L.W., Dembitsky, W., et al. (2001) Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure. New England Journal of Medicine, 345, 1435-1443. https://doi.org/10.1056/nejmoa012175 |
| [5] | 周诚, 尚小珂, 张箐, 等. 植入式左心室辅助装置现状与进展[J]. 中国胸心血管外科临床杂志, 2023, 30(9): 1351-1354. |
| [6] | Boulet, J., Nayak, A. and Mehra, M.R. (2022) Hemodynamic Aberrancies in Left Ventricular Assist Device-Associated Heart Failure Syndromes. Journal of Cardiac Failure, 28, 1738-1740. https://doi.org/10.1016/j.cardfail.2022.09.007 |
| [7] | Gupta, S., Cogswell, R.J., Roy, S.S., Spratt, J.R., Liao, K.K., Martin, C.M., et al. (2019) Impact of 30 Day Readmission after Left Ventricular Assist Device Implantation. ASAIO Journal, 65, 252-256. https://doi.org/10.1097/mat.0000000000000812 |
| [8] | Takeda, K., Naka, Y., Yang, J.A., Uriel, N., Colombo, P.C., Jorde, U.P., et al. (2014) Outcome of Unplanned Right Ventricular Assist Device Support for Severe Right Heart Failure after Implantable Left Ventricular Assist Device Insertion. The Journal of Heart and Lung Transplantation, 33, 141-148. https://doi.org/10.1016/j.healun.2013.06.025 |
| [9] | de By, T.M.M.H., Mohacsi, P., Gummert, J., Bushnaq, H., Krabatsch, T., Gustafsson, F., et al. (2015) The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): First Annual Report. European Journal of Cardio-Thoracic Surgery, 47, 770-777. https://doi.org/10.1093/ejcts/ezv096 |
| [10] | LaRue, S.J., Raymer, D.S., Pierce, B.R., Nassif, M.E., Sparrow, C.T. and Vader, J.M. (2017) Clinical Outcomes Associated with Intermacs-Defined Right Heart Failure after Left Ventricular Assist Device Implantation. The Journal of Heart and Lung Transplantation, 36, 475-477. https://doi.org/10.1016/j.healun.2016.12.017 |
| [11] | Capriotti, T. and Micari, M. (2019) Chronic Heart Failure Treatment with the Left Ventricular Assist Device. Home Healthcare Now, 37, 190-197. https://doi.org/10.1097/nhh.0000000000000777 |
| [12] | DeFilippis, E.M., Guazzi, M., Colombo, P.C. and Yuzefpolskaya, M. (2020) A Right Ventricular State of Mind in the Progression of Heart Failure with Reduced Ejection Fraction: Implications for Left Ventricular Assist Device Therapy. Heart Failure Reviews, 26, 1467-1475. https://doi.org/10.1007/s10741-020-09935-x |
| [13] | Miller, T., Lang, F.M., Rahbari, A., Theodoropoulos, K. and Topkara, V.K. (2024) Right Heart Failure after Durable Left Ventricular Assist Device Implantation. Expert Review of Medical Devices, 21, 197-206. https://doi.org/10.1080/17434440.2024.2305362 |
| [14] | Lorusso, R., Ravaux, J.M. and Mariani, S. (2021) Left Ventricular Assist Devices and Right Ventricular Failure Prediction: Quo Vadis? Interactive Cardio Vascular and Thoracic Surgery, 33, 793-794. https://doi.org/10.1093/icvts/ivab208 |
| [15] | Kapelios, C.J., Lund, L.H., Wever-Pinzon, O., Selzman, C.H., Myers, S.L., Cantor, R.S., et al. (2022) Right Heart Failure Following Left Ventricular Device Implantation: Natural History, Risk Factors, and Outcomes: An Analysis of the STS INTERMACS Database. Circulation: Heart Failure, 15, e008706. https://doi.org/10.1161/circheartfailure.121.008706 |
| [16] | Dell’Italia, L.J. (2012) Anatomy and Physiology of the Right Ventricle. Cardiology Clinics, 30, 167-187. https://doi.org/10.1016/j.ccl.2012.03.009 |
| [17] | Sheehan, F. and Redington, A. (2008) The Right Ventricle: Anatomy, Physiology and Clinical Imaging. Heart, 94, 1510-1515. https://doi.org/10.1136/hrt.2007.132779 |
| [18] | Liu, H., Jones, T.E., Jeng, E., Peng, K.L. and Peng, Y.G. (2021) Risk Stratification and Optimization to Prevent Right Heart Failure during Left Ventricular Assist Device Implantation. Journal of Cardiothoracic and Vascular Anesthesia, 35, 3385-3393. https://doi.org/10.1053/j.jvca.2020.09.130 |
| [19] | Brisco, M.A., Sundareswaran, K.S., Milano, C.A., Feldman, D., Testani, J.M., Ewald, G.A., et al. (2014) The Incidence, Risk, and Consequences of Atrial Arrhythmias in Patients with Continuous-Flow Left Ventricular Assist Devices. Journal of Cardiac Surgery, 29, 572-580. https://doi.org/10.1111/jocs.12336 |
| [20] | Hamdan, R., Charif, F. and Kadri, Z. (2020) Right Ventricle Failure in Patients Treated with Left Ventricular Assist Device. Annales de Cardiologie et d’Angéiologie, 69, 51-54. https://doi.org/10.1016/j.ancard.2020.01.008 |
| [21] | Bahl, A., Qureshi, B., Zhang, K., Bravo, C., Mahr, C. and Li, S. (2022) Explainable Machine Learning Analysis of Right Heart Failure after Left Ventricular Assist Device Implantation. ASAIO Journal, 69, 417-423. https://doi.org/10.1097/mat.0000000000001843 |
| [22] | Gumus, F., Sarıcaoglu, C., Inan, M.B. and Akar, A.R. (2019) Right Ventricular Strain to Assess Early Right Heart Failure in the Left Ventricular Assist Device Candidate. Current Heart Failure Reports, 16, 212-219. https://doi.org/10.1007/s11897-019-00445-y |
| [23] | Kumar, N., Iyer, M.H., Hussain, N. and Essandoh, M. (2022) Predicting Right Ventricular Failure after Left Ventricular Assist Device Implantation: Are We There Yet? Heart, Lung and Circulation, 31, e143-e144. https://doi.org/10.1016/j.hlc.2022.06.673 |
| [24] | Houston, B.A., Shah, K.B., Mehra, M.R. and Tedford, R.J. (2017) A New “Twist” on Right Heart Failure with Left Ventricular Assist Systems. The Journal of Heart and Lung Transplantation, 36, 701-707. https://doi.org/10.1016/j.healun.2017.03.014 |
| [25] | Singh, S.K. and Takeda, K. (2022) Right Heart Failure after Left Ventricular Assist Device Implantation—From Prediction to Action. The Journal of Heart and Lung Transplantation, 41, 1727-1728. https://doi.org/10.1016/j.healun.2022.08.012 |
| [26] | Balthazar, T., Adriaenssens, T., Rega, F. and Vandenbriele, C. (2020) Pulsus Alternans as a Sign of Right Ventricular Failure after Left Ventricular Assist Device Implantation. Journal of Cardiac Failure, 26, 1093-1095. https://doi.org/10.1016/j.cardfail.2020.09.010 |
| [27] | Trachtenberg, B., Jennings, D., Grafton, G., Loyaga-Rendon, R., Cogswell, R., Klein, L., et al. (2023) Corrigendum to “HFSA Expert Consensus Statement on the Medical Management of Patients on Durable Mechanical Circulatory Support”. Journal of Cardiac Failure, 29, Article 1342. https://doi.org/10.1016/j.cardfail.2023.06.004 |
| [28] | Turner, K.R. (2019) Right Ventricular Failure after Left Ventricular Assist Device Placement—The Beginning of the End or Just Another Challenge? Journal of Cardiothoracic and Vascular Anesthesia, 33, 1105-1121. https://doi.org/10.1053/j.jvca.2018.07.047 |
| [29] | Schmack, B., Weymann, A., Popov, A., Patil, N.P., Sabashnikov, A., Kremer, J., et al. (2016) Concurrent Left Ventricular Assist Device (LVAD) Implantation and Percutaneous Temporary RVAD Support via Cardiacassist Protek-Duo Tandemheart to Preempt Right Heart Failure. Medical Science Monitor Basic Research, 22, 53-57. https://doi.org/10.12659/msmbr.898897 |
| [30] | Alkhunaizi, F.A., Azih, N.I., Read, J.M., Goldberg, R.L., Gulati, A.A., Scheel, P.J., et al. (2022) Characteristics and Predictors of Late Right Heart Failure after Left Ventricular Assist Device Implantation. ASAIO Journal, 69, 315-323. https://doi.org/10.1097/mat.0000000000001804 |
| [31] | Hayek, S., Sims, D.B., Markham, D.W., Butler, J. and Kalogeropoulos, A.P. (2014) Assessment of Right Ventricular Function in Left Ventricular Assist Device Candidates. Circulation: Cardiovascular Imaging, 7, 379-389. https://doi.org/10.1161/circimaging.113.001127 |
| [32] | Hatano, M., Jimba, T., Fujiwara, T., Tsuji, M., Bujo, C., Ishida, J., et al. (2022) Late-Onset Right Ventricular Failure after Continuous-Flow Left Ventricular Assist Device Implantation: Case Presentation and Review of the Literature. Journal of Cardiology, 80, 110-115. https://doi.org/10.1016/j.jjcc.2021.12.009 |
