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JNK/c-Jun信号通路在肾脏疾病发生发展中的调控作用
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Abstract:
JNK是MAPK超家族成员之一，c-Jun是JNK的主要下游因子，是一种受JNK调控的即早基因。JNK和c-Jun是创伤、应激、细胞凋亡相关的调节因子，参与调控多种疾病的发生发展过程。近年来，研究发现，JNK/c-Jun信号通路在IgA肾病、抗GBM肾小球肾炎、肾纤维化、急性肾损伤等多种肾脏疾病中表现为异常活化，调控着相关肾脏疾病的发生和发展过程。本文就JNK/c-Jun信号通路在肾脏疾病发生发展过程中的调控作用作简要综述。
JNK is one of the members of the MAPK superfamily, and c-Jun is the main downstream factor of JNK, which is an early gene regulated by JNK. JNK and c-Jun are regulators related to trauma, stress and apoptosis, and are involved in regulating the occurrence and development of a variety of diseases. In recent years, studies have found that the JNK/c-Jun signaling pathway is abnormally activated in a variety of kidney diseases, such as IgA nephropathy, anti-GBM glomerulonephritis, renal fibrosis, and acute kidney injury, which regulates the occurrence and development of related kidney diseases. This article briefly reviews the regulatory role of JNK/c-Jun signaling pathway in the occurrence and development of kidney diseases.
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