%0 Journal Article
%T JNK/c-Jun信号通路在肾脏疾病发生发展中的调控作用<br>Regulatory Role of JNK/c-Jun Signaling Pathway in the Occurrence and Development of Kidney Disease
%A 关雅洁
%A 金春花
%J Advances in Clinical Medicine
%P 371-376
%@ 2161-8720
%D 2024
%I Hans Publishing
%R 10.12677/acm.2024.14102667
%X JNK是MAPK超家族成员之一&#65292;c-Jun是JNK的主要下游因子&#65292;是一种受JNK调控的即早基因。JNK和c-Jun是创伤、应激、细胞凋亡相关的调节因子&#65292;参与调控多种疾病的发生发展过程。近年来&#65292;研究发现&#65292;JNK/c-Jun信号通路在IgA肾病、抗GBM肾小球肾炎、肾纤维化、急性肾损伤等多种肾脏疾病中表现为异常活化&#65292;调控着相关肾脏疾病的发生和发展过程。本文就JNK/c-Jun信号通路在肾脏疾病发生发展过程中的调控作用作简要综述。<br>JNK is one of the members of the MAPK superfamily, and c-Jun is the main downstream factor of JNK, which is an early gene regulated by JNK. JNK and c-Jun are regulators related to trauma, stress and apoptosis, and are involved in regulating the occurrence and development of a variety of diseases. In recent years, studies have found that the JNK/c-Jun signaling pathway is abnormally activated in a variety of kidney diseases, such as IgA nephropathy, anti-GBM glomerulonephritis, renal fibrosis, and acute kidney injury, which regulates the occurrence and development of related kidney diseases. This article briefly reviews the regulatory role of JNK/c-Jun signaling pathway in the occurrence and development of kidney diseases.
%K JNK/c-Jun信号通路&#65292
%K IgA肾病&#65292
%K 抗GBM肾小球肾炎&#65292
%K 肾纤维化&#65292
%K 急性肾损伤&#65292
%K 调控作用<br>JNK/c-Jun Signaling Pathway
%K IgA Nephropathy
%K Anti-GBM Glomerulonephritis
%K Renal Fibrosis
%K Acute Kidney Injury
%K Regulatory Role
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=97666