|
|
苗药高朗加结合参苓白术散软糖对轻度敏感型肌肤屏障受损的干预研究
|
Abstract:
目的：观察苗药高朗加结合参苓白术散软糖对轻度敏感型肌肤屏障受损的干预作用。方法：将符合纳入标准的72例轻度敏感型肌肤人群分为试验组和对照组。将所用汤剂制成软糖供受试者食用，一日两粒，7 d为一个周期，整个测试过程共3个周期。于第一周、第二周、第三周分别测定肌肤经表皮失水率(transepidermal water loss, TEWL)及皮肤角质层水合度(skin cuticle hydration, SCH)。结果：试验组受试者的TEWL在受试后第三周与受试前、受试后第一周、受试后第二周时比较有明显下降，比较差异有统计学意义(均P < 0.05)；试验组受试者的SCH在受试后第三周与受试前、受试后第一周、受试后第二周时比较有明显升高，比较差异有统计学意义(均P < 0.05)。结论：苗药高朗加结合参苓白术散软糖可降低轻度敏感型肌肤TEWL，同时升高SCH，具有修复皮肤屏障受损的作用。
Objective: To observe the intervention effect of Miao medicine Gao Langjia combined with Shenling Baizhu powder gummies on mild sensitive skin barrier damage. Methods: A total of 72 patients with mildly sensitive skin who met the inclusion criteria were divided into experimental group and control group. The decoction made by Gao Langjia combined with Shenling Baizhu powder was made into jelly drops for the subjects to eat, two capsules a day, 7 days as a cycle, and the whole test process was a total of 3 cycles. The transepidermal water loss (TEWL) and skin cuticle hydration (SCH) of the stratum corneum were measured in the first, second and third weeks, respectively. Results: The TEWL of the subjects in the experimental group was significantly lower in the third week after the test than before the test, the first week after the test, and the second week after the test, and the difference was statistically significant (all P < 0.05); the SCH of the subjects in the experimental group was significantly higher in the third week after the test than before the test, the first week after the test, and the second week after the test, and the difference was statistically significant (all P < 0.05). Conclusion: The combination of Miao medicine Gao Langjia and Shenling Baizhu powder gummies can reduce the TEWL and increase the SCH in mildly sensitive skin, which has the effect of repairing the damaged skin barrier.
| [1] | 孙丹, 曹毅, 陶茂灿, 等. 敏感肌肤病因研究进展[J]. 浙江中西医结合杂志, 2016, 26(9): 866-869. |
| [2] | Fan, L., He, C., Jiang, L., Bi, Y., Dong, Y. and Jia, Y. (2015) Brief Analysis of Causes of Sensitive Skin and Advances in Evaluation of Anti-Allergic Activity of Cosmetic Products. International Journal of Cosmetic Science, 38, 120-127. https://doi.org/10.1111/ics.12283 |
| [3] | Seidenari, S., Francomano, M. and Mantovani, L. (1998) Baseline Biophysical Parameters in Subjects with Sensitive Skin. Contact Dermatitis, 38, 311-315. https://doi.org/10.1111/j.1600-0536.1998.tb05764.x |
| [4] | 胡曼丽. 黄紫乳膏治疗慢性局限性湿疹临床观察[D]: [硕士学位论文]. 武汉: 湖北中医药大学, 2020. |
| [5] | 李璨宇, 纳猛, 马颖, 等. 中医药修复皮肤屏障功能受损的研究进展[J]. 云南中医中药杂志, 2021, 42(8): 94-98. |
| [6] | 何丹. 脾虚与皮肤机械屏障功能关系的部分实验研究[D]: [硕士学位论文]. 成都: 成都中医药大学, 2008. |
| [7] | 栾梅, 戴茹, 范林明, 等. 敏感性皮肤问卷的编制及其与鲍曼敏感性皮肤问卷的信度和效度比较[J]. 中国皮肤性病学志, 2018, 32(1): 80-83. |
| [8] | 国家药典委员会. 中华人民共和国药典: 2020年版(一部) [M]. 北京: 中国医药科技出版社, 2020: 1223. |
| [9] | 喻明英, 许显, 任璐, 等. 敏感肌形成机制及抗敏感成分研究进展[J]. 日用化学品科学, 2021, 44(6): 32-37, 52. |
| [10] | 渡辺大輔, 石田耕一, 海津一宏, 等. 中国敏感皮肤女性的皮肤生理学特征以及含低刺激神经酰胺化妆品对其改善效果[C]//中国中西医结合学会. 2023全国中西医结合皮肤性病学术会议论文汇编. 花王公司, 花王(中国)研究开发中心有限公司, 上海市皮肤病医院, 2023: 83-90. |
| [11] | Cho, H.J., Chung, B.Y., Lee, H.B., Kim, H.O., Park, C.W. and Lee, C.H. (2011) Quantitative Study of Stratum Corneum Ceramides Contents in Patients with Sensitive Skin. The Journal of Dermatology, 39, 295-300. https://doi.org/10.1111/j.1346-8138.2011.01406.x |
| [12] | 曹俊, 朱学骏. 经皮水分丢失与健康人性别、年龄、解剖部位的关系[J]. 临床皮肤科杂志, 2002, 31(1): 9-10. |
| [13] | 刘媛, 解宇环, 何丹, 等. 参苓白术散对皮肤机械屏障功能障碍小鼠皮肤水分的影响[J]. 云南中医中药杂志, 2017, 38(8): 75-77. |
| [14] | 朱铭华. 浅谈皮肤病从脾论治[J]. 江苏中医药, 2005, 26(8): 42-43. |
| [15] | 杨皓然. 健脾方对小鼠皮肤屏障功能干预作用的实验研究[D]: [硕士学位论文]. 昆明: 云南中医学院, 2016. |
| [16] | 刘媛. 参苓白术散对皮肤机械屏障功能障碍小鼠皮肤神经酰胺代谢途径的影响研究[D]: [硕士学位论文]. 昆明:云南中医学院, 2018. |
| [17] | 闫君杰, 朱明芳. 朱明芳教授基于脾胃为气机升降之枢纽治疗特应性皮炎经验[J]. 光明中医, 2024, 39(10): 1952-1955. |
| [18] | 罗文峰, 张芸, 蓝尉, 等. 参苓白术散联合复方毛麝香外洗颗粒治疗脾虚湿蕴型特应性皮炎临床疗效观察[J]. 辽宁中医药大学学报, 2023, 25(12): 10-14. |
