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附子理中汤治疗溃疡性结肠炎的研究进展
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Abstract:
溃疡性结肠炎是一种终身复发性的肠道器质性疾病，附子理中汤治疗此病具有独特优势。药理学研究表明附子理中汤治疗溃疡性结肠炎的机制包括抑制炎症因子的产生及调控相关细胞信号通路、改善肠道免疫环境、调节肠道菌群、保护肠黏膜屏障功能等。现代临床应用表明，除附子理中汤原方外，其加减方也可用于治疗溃疡性结肠炎，并常与其他中药复方、西药、中医特色疗法等联合应用，临床疗效佳。本文就附子理中汤治疗溃疡性结肠炎的病机探讨、基础研究进展及临床应用进行系统综述。
Ulcerative colitis is a lifelong recurrent organic disease of the intestine, and the Fuzi Lizhong Decoction has unique advantages in treating this disease. Pharmacological studies have shown that mechanisms involved in the treatment of ulcerative colitis with the Fuzi Lizhong Decoction include inhibiting production of inflammatory factors and regulating relevant cell signaling pathways, improving the intestinal immune environment, regulating intestinal flora, protecting the barrier function of the intestinal mucosa, etc. Modern clinical applications have shown that in addition to the original formula of Fuzi Lizhong Decoction, its addition and subtraction formula can also be used to treat ulcerative colitis, and often combined with other Chinese medicine compounds, western medicine, Chinese medicine specialty therapy, etc., and has good clinical efficacy. This article provides a systematic review of the pathogenesis, basic research progress and clinical application of the treatment of ulcerative colitis with the Fuzi Lizhong Decoction.
| [1] | Gajendran, M., Loganathan, P., Jimenez, G., et al. (2019) A Comprehensive Review and Update on Ulcerative Colitis. Disease-a-Month, 65, Article ID: 100851. https://doi.org/10.1016/j.disamonth.2019.02.004 |
| [2] | 刘笃佳, 王媛媛, 马旭. 溃疡性结肠炎的流行病学研究进展[J]. 中国烧伤创疡杂志, 2017, 29(3): 214-217. |
| [3] | Nasseri-Moghaddam, S. (2012) Inflammatory Bowel Disease. Middle East Journal of Digestive Diseases, 4, 77-89. https://doi.org/10.1056/NEJM199202203260815 |
| [4] | Burri, E., Maillard, M., Schoepfer, A., et al. (2020) Treatment Algorithm for Mild and Moderate-to-Severe Ulcerative Colitis: An Update. Digestion, 101, 1-14. https://doi.org/10.1159/000504092 |
| [5] | 汪云伟, 王兴灵, 何娅, 等. 附子理中汤(丸)药理作用与临床应用研究进展[J]. 中药与临床, 2022, 13(4): 71-76. |
| [6] | 岳雁, 徐智广, 王芳玲, 等. 脾肾阳虚型溃疡性结肠炎的中医研究进展[J]. 中西医结合心血管病电子杂志, 2020, 8(16): 12-13. https://doi.org/10.16282/j.cnki.cn11-9336/r.2020.16.005 |
| [7] | 张声生, 沈洪, 郑凯, 等. 溃疡性结肠炎中医诊疗专家共识意见(2017) [J]. 中华中医药杂志, 2017, 32(8): 3585-3589. |
| [8] | 张学兰. 溃疡性结肠炎患者血清促炎因子与抗炎因子的表达及其关系[J]. 山东医药, 2014, 54(5): 54-55. |
| [9] | 张玉洁, 刘兴山. 溃疡性结肠炎的发病机制及中医药干预进展[J/OL]. 实用中医内科杂志, 2024: 1-5. http://kns.cnki.net/kcms/detail/21.1187.R.20240325.1644.006.html, 2024-03-27. |
| [10] | 朱丹. 附子理中汤灌肠对溃疡性结肠炎脾肾阳虚型大鼠血清TNF-α、IL-1β、IL-6水平的影响[D]: [硕士学位论文]. 成都: 成都中医药大学, 2016. |
| [11] | 谢文娟, 张志敏, 武志娟. 附子理中汤对D-IBS大鼠血清TNF-α、IL-10的影响[J]. 中国中医急症, 2013, 22(8): 1287-1288 1316. |
| [12] | 刘青松, 郝彦伟, 张怡, 等. 基于网络药理学和实验验证探讨加味附子理中汤治疗阳虚型溃疡性结肠炎的作用机制[J]. 中药药理与临床, 2022, 38(5): 32-38. https://doi.org/10.13412/j.cnki.zyyl.20220419.003 |
| [13] | 郝彦伟, 张怡, 周雪雷, 等. 基于mTOR/p-S6K1探讨加味附子理中汤干预UC大鼠肠黏膜炎症反应的效应机制[J]. 中国实验方剂学杂志, 2020, 26(13): 59-65. https://doi.org/10.13422/j.cnki.syfjx.20201340 |
| [14] | 姬培震. 附子理中汤灌肠对溃疡性结肠炎脾肾阳虚型大鼠结肠黏膜NF-κB血清IL-8表达影响的实验研究[D]: [硕士学位论文]. 成都: 成都中医药大学, 2017. |
| [15] | 冉倩, 梁鸽, 张翠涵, 等. 基于液质联用技术和网络药理学的附子理中汤干预溃疡性结肠炎的活性成分和作用机制研究[J]. 中国抗生素杂志, 2023, 48(12): 1393-1402. https://doi.org/10.13461/j.cnki.cja.007614 |
| [16] | Shou, X., Wang, Y., Zhang, X., et al. (2022) Network Pharmacology and Molecular Docking Analysis on Molecular Mechanism of Qingzi Zhitong Decoction in the Treatment of Ulcerative Colitis. Frontiers in Pharmacology, 13, Article ID: 727608. https://doi.org/10.3389/fphar.2022.727608 |
| [17] | Saravia, J., Chapman, N.M. and Chi, H. (2019) Helper T Cell Differentiation. Cellular and Molecular Immunology, 16, 634-643. https://doi.org/10.1038/s41423-019-0220-6 |
| [18] | 王颖, 韩秀萍. 甘草酸苷作用机制的研究进展[J]. 实用药物与临床, 2018, 21(1): 109-113. https://doi.org/10.14053/j.cnki.ppcr.201801027 |
| [19] | 王彩云, 连宁芳, 王碧瑛, 等. 重症支气管哮喘患者CD4T淋巴细胞免疫功能分析[J]. 免疫学杂志, 2019, 35(2): 157-162. https://doi.org/10.13431/j.cnki.immunol.j.20190025 |
| [20] | 张艳晓, 方锐洁, 白少玉, 等. 附子理中汤灌肠调控溃疡性结肠炎大鼠IL-6、IL-8及ICAM-1的实验研究[J]. 中国中医基础医学杂志, 2016, 22(3): 351-354. https://doi.org/10.19945/j.cnki.issn.1006-3250.2016.03.022 |
| [21] | Huang, J.-W., et al. (2019) Study on the Mechanism of Fu Zi Li Zhong Decoction in Treating Gastric Ulcer and Its Effect on Gastrointestinal Microecology. Digital Chinese Medicine, 2, 147-156. https://doi.org/10.1016/j.dcmed.2019.12.003 |
| [22] | 孙艺凡, 张霞, 王晓艳, 等. 长期服用人参提取物对大鼠肠道菌群结构的影响[J]. 中国中药杂志, 2018, 43(19): 3927-3932. https://doi.org/10.19540/j.cnki.cjcmm.20180604.001 |
| [23] | 尹康, 陈科力, 刘焱文, 等. 白术对慢传输型便秘小鼠短链脂肪酸和肠道屏障的影响[J/OL]. 中国实验方剂学杂志, 2023: 1-9. https://doi.org/10.13422/j.cnki.syfjx.20240265 |
| [24] | Cheng, H., Liu, J., Zhang, D., et al. (2022) Ginsenoside Rg1 Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Microbial Tryptophan Metabolism. Frontiers in Immunology, 13, Article ID: 817600. https://doi.org/10.3389/fimmu.2022.817600 |
| [25] | 李水芹, 王飞, 李雪萍, 等. 附子理中汤外用治疗溃疡性结肠炎[J]. 江西中医学院学报, 2012, 24(5): 38-39 |
| [26] | 赵广刚. 附子理中汤治疗溃疡性结肠炎的临床疗效及其安全性[J]. 临床合理用药杂志, 2019, 12(24): 28-29. https://doi.org/10.15887/j.cnki.13-1389/r.2019.24.013 |
| [27] | 肖福香, 万莉华, 陈舞燕. 加味附子理中汤应用于脾肾阳虚型溃疡性结肠炎治疗的有效性分析[J]. 数理医药学杂志, 2016, 29(6): 874-875. |
| [28] | 王梦媛. 荆防附子理中汤治疗溃疡性结肠炎阳虚湿滞证的疗效及机制研究[D]: [博士学位论文]. 北京: 北京中医药大学, 2022. https://doi.org/10.26973/d.cnki.gbjzu.2022.000050 |
| [29] | 余沅林. 附子理中汤加味联合柳氮磺胺吡啶治疗溃疡性结肠炎的效果观察[J]. 当代医学, 2016, 22(35): 192-193. |
| [30] | 张茹, 李春耕. 中西医结合治疗慢性非特异性溃疡性结肠炎50例[J]. 河南中医, 2015, 35(6): 1399-1400. https://doi.org/10.16367/j.issn.1003-5028.2015.06.0586 |
| [31] | 高玉霞. 乌梅丸合附子理中汤加减治疗慢性溃疡性结肠炎35例疗效观察[J]. 临床研究, 2017, 25(1): 2-3. |
| [32] | 刘继业, 李丰林. 附子理中汤合四神丸加味治疗脾肾阳虚型溃疡性结肠炎临床观察[J]. 中国肛肠病杂志, 2016, 36(9): 38-41. https://doi.org/10.3969/j.issn.1000-1174.2016.09.017 |
| [33] | 李一鸣, 李珩. 加味附子理中汤联合艾灸应用于脾肾阳虚型溃疡性结肠炎治疗的有效性分析[J]. 内蒙古中医药, 2022, 41(11): 62-63. https://doi.org/10.16040/j.cnki.cn15-1101.2022.11.066 |
| [34] | 张雪, 屈银宗. 加味附子理中汤联合穴位敷贴治疗溃疡性结肠炎临床观察[J]. 中医临床研究, 2022, 14(28): 121-124. |
