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皮肤晚期糖基化终末产物在预测2型糖尿病患者血管并发症中作用的研究进展
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Abstract:
皮肤晚期糖基化终末产物(AGEs)是由还原糖和蛋白质等氨基通过不可逆的化学反应产生的最终产物。它能够通过各种方式对人体的糖代谢产生影响。研究发现，在患有糖尿病和相关血管并发症的人群中，AGEs的水平通常会有明显的上升。这类异常增高的AGEs不仅导致了血管的快速老化，还触发了一连串的炎症反应，从而加速了相关并发症的发展。因此，有必要了解其作用机制并加以防治。本文深入探讨了AGEs的生成、积累以及它们对糖代谢和血管的伤害机制，旨在为未来预防和治疗糖尿病及其导致的动脉粥样硬化提供新的研究方向。
Advanced glycation end products (AGEs) of the skin are the final products produced by irreversible chemical reactions of amino groups such as reducing sugars and proteins. It can affect the human body’s sugar metabolism in various ways. The study found that the level of AGEs usually increased significantly in people with diabetes and related vascular complications. These abnormally elevated AGEs not only lead to rapid aging of blood vessels, but also trigger a series of inflammatory reactions, thereby accelerating the development of related complications. Therefore, it is necessary to understand its mechanism of action and take preventive measures. In this paper, the generation and accumulation of AGEs and their damage mechanism to glucose metabolism and blood vessels were discussed in depth, aiming to provide a new research direction for the prevention and treatment of diabetes and atherosclerosis caused by it in the future.
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