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感染与MOGAD相关性的研究进展
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Abstract:
髓鞘少突胶质细胞糖蛋白免疫球蛋白G抗体相关疾病(MOGAD)是由免疫介导的中枢神经系统的炎性脱髓鞘疾病，但其具体的病因及发病机制尚不明确。近年来，感染后发生MOGAD的报道越来越多，甚至有感染同期合并MOGAD的报道。感染在MOGAD发病中的作用渐渐被重视，尤其对感染后继发MOGAD，以及感染病程中合并MOGAD的免疫治疗具有重要指导意义。本文对感染与MOGAD的相关性研究进行综述，探讨感染在MOGAD中所扮演的角色及可能存在的发病机制，为临床实践提供一定证据。
Myelin oligodendrocyte glycoprotein immunoglobulin G antibody-associated disease (MOGAD) is an immune-mediated inflammatory demyelinating disease of the central nervous system. However, its specific etiology and pathogenesis are still unclear. In recent years, there have been increasing reports of MOGAD following infection, and even cases of MOGAD occurring simultaneously with infection. The role of infection in the pathogenesis of MOGAD has gradually received attention, particularly regarding the immunotherapy of MOGAD secondary to infection and MOGAD during the course of an infection. This article reviews the research on the correlation between infection and MOGAD, discusses the role of infection in MOGAD, the possible pathogenesis, and provides evidence for clinical practice.
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