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PI3K/AKT/mTOR通路在胃癌中的研究进展
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Abstract:
胃癌居全球发病谱的第5位，死因谱的第4位。随着对胃癌发病机制的研究发现，PI3K/AKT/mTOR与胃癌的发生密切相关。该通路活化后，抑制胃癌细胞的凋亡、加速细胞周期的进程，促进血管形成，参与胃癌的侵袭和转移。本文对PI3K/AKT/mTOR通路的结构特点及其对胃癌发生、发展的作用做一综述。
Gastric cancer ranks fifth in the global pathogenesis spectrum and the forth place in the cause of death spectrum. With the study of the pathogenesis of gastric cancer, PI3K/AKT/mTOR is closely related to the occurrence of gastric cancer. After the pathway is activated, it inhibits the apoptosis of gastric cancer cells, accelerates the cell cycle, and promotes angiogenesis, involved in the invasion and metastasis of gastric cancer. This article reviews the structural characteristics of PI3K/ AKT/mTOR pathway and its occurrence and development of gastric cancer.
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