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纳米递送系统在肿瘤免疫治疗中的应用
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Abstract:
免疫疗法已成为治疗癌症的有力临床策略。免疫治疗药物批准的数量一直在增加，在临床和临床前开发中出现了许多治疗方法。然而，广泛实施癌症免疫疗法的一个关键挑战仍然是免疫系统的受控调节，因为这些疗法具有严重的副作用，包括自身免疫和非特异性炎症。先进的生物材料和药物输送系统，例如纳米颗粒和使用T细胞进行治疗，可以有效地利用免疫疗法并提高其效力，同时减少毒副作用。在这里，我们讨论了这些研究进展，以及将纳米递送技术运用于肿瘤免疫治疗中机遇与挑战以及应用，以改善肿瘤免疫治疗的不足。
Immunotherapy has become a powerful clinical strategy for the treatment of cancer. The number of approved immunotherapy drugs has been increasing, and many treatments have emerged in clinical and preclinical development. However, a key challenge to the widespread implementation of cancer immunotherapy remains the controlled regulation of the immune system, as these treatments have serious side effects, including autoim-munity and non-specific inflammation. Advanced biomaterials and drug delivery systems, such as nanoparticles and treatment with T cells, can effectively use immunotherapy and improve its effectiveness while reducing side effects. Here, we discuss the research progress, as well as the opportunities, challenges and applications of nano-delivery technology in tumor immunotherapy in order to improve the shortcomings of tumor immunotherapy.
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