%0 Journal Article
%T 纳米递送系统在肿瘤免疫治疗中的应用<br> Application of Nano-Delivery System in Tumor Immunotherapy
%A 袁豪华
%A 李林照
%A 聂瑛洁
%A 桂欢
%J Hans Journal of Nanotechnology
%P 97-109
%@ 2161-0878
%D 2023
%I Hans Publishing
%R 10.12677/NAT.2023.134010
%X 免疫疗法已成为治疗癌症的有力临床策略。免疫治疗药物批准的数量一直在增加，在临床和临床前开发中出现了许多治疗方法。然而，广泛实施癌症免疫疗法的一个关键挑战仍然是免疫系统的受控调节，因为这些疗法具有严重的副作用，包括自身免疫和非特异性炎症。先进的生物材料和药物输送系统，例如纳米颗粒和使用T细胞进行治疗，可以有效地利用免疫疗法并提高其效力，同时减少毒副作用。在这里，我们讨论了这些研究进展，以及将纳米递送技术运用于肿瘤免疫治疗中机遇与挑战以及应用，以改善肿瘤免疫治疗的不足。<br />
Immunotherapy has become a powerful clinical strategy for the treatment of cancer. The number of approved immunotherapy drugs has been increasing, and many treatments have emerged in clinical and preclinical development. However, a key challenge to the widespread implementation of cancer immunotherapy remains the controlled regulation of the immune system, as these treatments have serious side effects, including autoim-munity and non-specific inflammation. Advanced biomaterials and drug delivery systems, such as nanoparticles and treatment with T cells, can effectively use immunotherapy and improve its effectiveness while reducing side effects. Here, we discuss the research progress, as well as the opportunities, challenges and applications of nano-delivery technology in tumor immunotherapy in order to improve the shortcomings of tumor immunotherapy.
%K 肿瘤，纳米递送，免疫治疗，理化性质<>br
%K Tumour
%K Nano-Delivery
%K Immunotherapy
%K Physico-chemical Properties
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=76240