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血清sFRP-4水平及结缔组织生长因子与2型糖尿病肾病的关系研究进展
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Abstract:
糖尿病肾脏疾病(diabetic kidney disease, DKD)作为糖尿病(diabetes mellitus, DM)最常见的慢性并发症之一，是引起终末期肾脏疾病(end-stage renal disease, ESRD)的主要原因。伴随DKD患者数量的增长，在很大程度上增加了ESRD的患病率。因此，早期评估DM患者的肾脏功能以便及时发现并治疗，减少DKD的患病率。本文将总结近几年关于DKD发生机制的最新进展与血清分泌型卷曲相关蛋白-4 (secreted frizzled-related protein 4, sFRP-4)及结缔组织生长因子(connective tissue growth factor, CTGF)作为检验指标与DKD的关系。
Diabetic kidney disease (DKD), as one of the most common chronic complications of diabetes melli-tus (DM), is a major cause of end-stage renal disease (ESRD). The growth in the number of patients with DKD has been accompanied by a significant increase in the prevalence of ESRD. Therefore, early assessment of renal function in DM patients allows for timely detection and treatment to re-duce the prevalence of DKD. In this paper, we will summarize the recent advances on the mecha-nism of DKD and the relationship between serum secreted frizzled-related protein 4 (sFRP-4) and connective tissue growth factor (CTGF) as tests and DKD.
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