%0 Journal Article
%T 血清sFRP-4水平及结缔组织生长因子与2型糖尿病肾病的关系研究进展<br>Progress of Research on the Relationship between Serum sFRP-4 Levels and Connective Tissue Growth Factor and Type 2 Diabetic Nephropathy
%A 任瑶瑶
%A 任杰
%A 魏剑芬
%J Advances in Clinical Medicine
%P 17584-17590
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.13112464
%X 糖尿病肾脏疾病(diabetic kidney disease, DKD)作为糖尿病(diabetes mellitus, DM)最常见的慢性并发症之一，是引起终末期肾脏疾病(end-stage renal disease, ESRD)的主要原因。伴随DKD患者数量的增长，在很大程度上增加了ESRD的患病率。因此，早期评估DM患者的肾脏功能以便及时发现并治疗，减少DKD的患病率。本文将总结近几年关于DKD发生机制的最新进展与血清分泌型卷曲相关蛋白-4 (secreted frizzled-related protein 4, sFRP-4)及结缔组织生长因子(connective tissue growth factor, CTGF)作为检验指标与DKD的关系。<br />
Diabetic kidney disease (DKD), as one of the most common chronic complications of diabetes melli-tus (DM), is a major cause of end-stage renal disease (ESRD). The growth in the number of patients with DKD has been accompanied by a significant increase in the prevalence of ESRD. Therefore, early assessment of renal function in DM patients allows for timely detection and treatment to re-duce the prevalence of DKD. In this paper, we will summarize the recent advances on the mecha-nism of DKD and the relationship between serum secreted frizzled-related protein 4 (sFRP-4) and connective tissue growth factor (CTGF) as tests and DKD.
%K 糖尿病肾脏疾病，分泌型卷曲相关蛋白-4，结缔组织生长因子<br>Diabetic Kidney Disease
%K Secreted Frizzled-Related Protein 4
%K Connective Tissue Growth Factor
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=75095