|
超声剪切波黏弹性成像在肝脏局灶性病变中的研究进展
|
Abstract:
鉴别肝脏局灶性病变(FLL)的良恶性一直是临床关注的重点,虽然肝活检对其有极高的准确性,但它是侵入性检查,有一定的危险性,因此很大程度上限制了在临床中的广泛应用。传统超声作为肝脏的一线检查方法,有着其他检查不可比拟的优势,但面对同病异征,同征异病的FLL,传统超声对其定性诊断面临着巨大挑战。超声剪切波黏弹性成像技术的出现,为超声检查评定组织性质提供了新的参考方向,在评估肝纤维化方面已经取得了令人满意的效果,对鉴别FLL的良恶性方面也表现出一定的潜力,本文就剪切波黏弹性成像在FLL中的研究进展及相关问题展开论述。
Identifying benign and malignant liver focal lesions (FLL) has always been the focus of clinical at-tention, although liver biopsy has extremely high accuracy for it, it is an invasive test and has cer-tain risks, so it greatly limits its wide application in clinical practice. As a first-line examination method for the liver, traditional ultrasound has incomparable advantages in other examinations, but in the face of FLL with the same symptoms and different diseases, traditional ultrasound faces great challenges in its qualitative diagnosis. The emergence of ultrasonic shear wave viscoelastic imaging technology provides a new reference direction for ultrasonography to evaluate tissue properties, and has achieved satisfactory results in the evaluation of liver fibrosis, and also shows certain potential for the identification of benign and malignant aspects of FLL. In this paper, the re-search progress of shear wave viscoelastic imaging in FLL and related problems are discussed.
[1] | Zhang, H.X., Zhu, J.Z., Xi, L.T., Xu, C.F. and Wu, A.R. (2019) Validation of the Toronto Hepatocellular Carcinoma Risk Index for Patients with Cirrhosis in China: A Retrospective Cohort Study. World Journal of Surgical Oncology, 17, Article No. 75. https://doi.org/10.1186/s12957-019-1619-3 |
[2] | Kim, G.A., Lee, H.C., Choe, J., et al. (2017) As-sociation between Non-Alcoholic Fatty Liver Disease and Cancer Incidence Rate. Journal of Hepatology. |
[3] | 蒋燕萍, 郑朝霞. 常规超声与超声造影检查在老年肝脏局灶性病变良恶性鉴别诊断中的应用价值[J]. 基层医学论坛, 2021, 25(29): 4230-4232. |
[4] | Chen, X., Shen, Y., Zheng, Y., et al. (2013) Quantification of Liver Viscoelasticity with Acoustic Radiation Force: A Study of Hepatic Fibrosis in a Rat Model. Ultrasound in Medicine and Biology, 39, 2091-2102.
https://doi.org/10.1016/j.ultrasmedbio.2013.05.020 |
[5] | Ferraioli, G., Filice, C., Castera, L., et al. (2015) WFUMB guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 3: Liver. Ultrasound in Medicine and Biology, 41, 1161-1179.
https://doi.org/10.1016/j.ultrasmedbio.2015.03.007 |
[6] | European Association for the Study of the Liver and Aso-ciacion Latinoamericana para el Estudio del Higado (2015) EASL-ALEH Clinical Practice Guidelines: Non-Invasive Tests for Evaluation of Liver Disease Severity and Prognosis. Journal of Hepatology, 63, 237-264. https://doi.org/10.1016/j.jhep.2015.04.006 |
[7] | Dietrich, C.F., Bamber, J., Berzigotti, A., et al. (2017) EFSUMB Guidelines and Recommendations on the Clinical Use of Liver Ultrasound Elastography, Update 2017 (Long Version). Ultraschall in der Medizin, 38, e16-e47.
https://doi.org/10.1055/s-0043-103952 |
[8] | 梁萍, 郑荣琴. 二维剪切波弹性成像评估慢性乙型肝炎肝纤维化临床应用指南[J]. 临床肝胆病杂志, 2018, 34(2): 255-261. |
[9] | Oprea, M., Vlad, M., Golu, I., Sporea, I. and Fulger, L. (2018) Diagnostic Value of Real-Time Shear Wave Elastography in Diagnosing Thyroid Cancer. Revista de Chimie, 68, 2818-2822. https://doi.org/10.37358/RC.17.12.5985 |
[10] | Golatta, M., Pfob, A., Büsch, C., et al. (2021) The Potential of Combined Shear Wave and Strain Elastography to Reduce Unnecessary Biopsies in Breast Cancer Diagnos-tics—An International, Multicentre Trial. European Journal of Cancer, 161, 1-9. https://doi.org/10.1016/j.ejca.2021.11.005 |
[11] | 陈何刚, 盛燕红, 张健瑀, 等. 经直肠剪切波超声弹性成像技术联合弹性模量在前列腺良恶性肿瘤中的鉴别应用[J]. 现代实用医学, 2023, 35(7): 939-941. |
[12] | 张琪, 董怡, 杨道辉, 于凌云, 邱艺杰, 王文平. 超声剪切波黏弹性技术在肝肿瘤良恶性鉴别中的初步临床应用[J]. 中华超声影像学杂志, 2019, 28(9): 766-770. |
[13] | Dong, Y., Qiu, Y., Zhang, Q., et al. (2020) Preliminary Clinical Experience with Shear Wave Dispersion Imaging for Liver Viscosity in Preoperative Diagnosis of Focal Liver Lesions. Zeitschrift für Gastroenterologie, 58, 847-854.
https://doi.org/10.1055/a-1217-7465 |
[14] | Guibal, A., Boularan, C., Bruce, M., et al. (2012) Evaluation of Shear-wave Elastography for the Characterisation of Focal Liver Lesions on Ultrasound. European Radiology, 23, 1138-1149. https://doi.org/10.1007/s00330-012-2692-y |
[15] | Keskin, S., Babaoglu, O. and Keskin, Z. (2022) An Investigation of the Efficacy of Shear Wave Elastography in the Characterization of Benign and Malignant Liver Lesions. Polish Jour-nal of Radiology, 87, e462-e468.
https://doi.org/10.5114/pjr.2022.119060 |
[16] | Guo, J., Jiang, D., Qian, Y., et al. (2022) Differential Diagnosis of Different Types of Solid Focal Liver Lesions Using Two-Dimensional Shear Wave Elastography. World Journal of Gastroenterology, 28, 4716-4725.
https://doi.org/10.3748/wjg.v28.i32.4716 |
[17] | Jesper, D., Fiedler, S., Klett, D., et al. (2021) Shear Wave Disper-sion Imaging for the Characterization of Focal Liver Lesions—A Pilot Study. Ultraschall in der Medizin, 43, 507-513. https://doi.org/10.1055/a-1610-9171 |
[18] | Wang, K., Yu, D., Li, G.F., et al. (2022) Comparison of the Diagnostic Performance of Shear Wave Elastography with Shear Wave Dispersion for Pre-Operative Staging of Hepatic Fibrosis in Patients with Hepatocellular Carcinoma. European Journal of Radiology, 154, Article ID: 110459. https://doi.org/10.1016/j.ejrad.2022.110459 |
[19] | Lu, Q., Ling, W., Lu, C., et al. (2015) Hepatocellular Carcinoma: Stiffness Value and Ratio to Discriminate Malignant from Benign Focal Liver Lesions. Radiology, 275, 880-888. https://doi.org/10.1148/radiol.14131164 |
[20] | Zhang, H.P., Gu, J.Y., Bai, M., et al. (2020) Value of Shear Wave Elastography with Maximal Elasticity in Differentiating Benign and Malignant Solid Focal Liver Lesions. World Journal of Gastroenterology, 26, 7416-7424.
https://doi.org/10.3748/wjg.v26.i46.7416 |
[21] | Tian, W.S., Lin, M.X., Zhou, L.Y., et al. (2016) Maximum Value Measured by 2-D Shear Wave Elastography Helps in Differentiating Malignancy from Benign Focal Liver Lesions. Ul-trasound in Medicine and Biology, 42, 2156-2166.
https://doi.org/10.1016/j.ultrasmedbio.2016.05.002 |
[22] | Wang, W., Zhang, J.C., Tian, W.S., et al. (2020) Shear Wave Elastography-Based Ultrasomics: Differentiating Malignant from Benign Focal Liver Lesions. Abdominal Radiol-ogy, 46, 237-248.
https://doi.org/10.1007/s00261-020-02614-3 |
[23] | Ronot, M., Di Renzo, S., Gregoli, B., et al. (2014) Characteriza-tion of Fortuitously Discovered Focal Liver Lesions: Additional Information Provided by Shearwave Elastography. Eu-ropean Radiology, 25, 346-358.
https://doi.org/10.1007/s00330-014-3370-z |
[24] | Ling, W., Lu, Q., Lu, C., et al. (2014) Effects of Vascularity and Differentiation of Hepatocellular Carcinoma on Tumor and Liver Stiffness: In vivo and in vitro Studies. Ultrasound in Medicine and Biology, 40, 739-746.
https://doi.org/10.1016/j.ultrasmedbio.2013.08.011 |
[25] | Naganuma, H., Ishida, H., Uno, A., et al. (2020) Diagnos-tic Problems in Two-Dimensional Shear Wave Elastography of the Liver. World Journal of Gastroenterology, 12, 76-86. https://doi.org/10.4329/wjr.v12.i5.76 |
[26] | Jiang, X., Li, L. and Xue, H.Y. (2022) The Impact of Body Position and Exercise on the Measurement of Liver Young’s Modulus by Real-Time Shear Wave Elastography. Technology and Health Care, 30, 445-454.
https://doi.org/10.3233/THC-213218 |
[27] | Kj?rgaard, M., Thiele, M., Jansen, C., et al. (2017) High Risk of Misin-terpreting Liver and Spleen Stiffness Using 2D Shear-Wave and Transient Elastography after a Moderate or High Calorie Meal. PLOS ONE, 12, e0173992.
https://doi.org/10.1371/journal.pone.0173992 |
[28] | Albayrak, E., S?nmezg?z, E., Akba?, M., et al. (2022) ?ocuk ve Eri?kin Ya? Gruplar?nda Karaci?er Elastisitesinin Karaci?er Boyutu, Ya?, Cinsiyet ve Beden Kitle ?ndeksi ile ?li?kisinin 2-D Shear Wave Elastografi ile De?erlendirilmesi Düzce T?p Fakültesi Dergisi.
https://newfmrs.metstr.com/search/detail?mid=fbd4c56bc6fa7ef4458f833eb848d2c1&searchExp=% C3%87ocuk%20ve%20Eri%C5%9Fkin%20Ya%C5%9F%20Gruplar %C4%B1nda%20Karaci%C4%9Fer%20Elastisitesinin%20%20 Karaci%C4%9Fer%20Boyutu,%20Ya%C5%9F,%20Cinsiyet%20 ve%20Beden%20Kitle%20%C4%B0ndeksi%20ile%20%C4%B0li %C5%9Fkisinin%202-D%20Shear%20&needPubmedParse=false&query=%C3%87ocuk %20ve%20Eri%C5%9Fkin%20Ya%C5%9F%20Gruplar%C4%B1nda %20Karaci%C4%9Fer%20Elastisitesinin%20%20Karaci%C4 %9Fer%20Boyutu,%20Ya%C5%9F,%20Cinsiyet%20ve%20Beden %20Kitle%20%C4%B0ndeksi%20ile%20%C4%B0li%C5%9Fkisinin %202-D%20Shear%20 |
[29] | 朱宇莉, 包静文, 王坤, 等. 超声剪切波弹性及频散成像技术检测健康成人肝脏黏弹性的参考值范围[J]. 中国临床医学, 2021, 28(5): 869-873. |
[30] | Ling, W.W., Lu, Q., Quan, J.R., Ma, L. and Luo, Y. (2012) Assessment of Impact Factors on Shear Wave Based Liver Stiffness Measurement. European Journal of Radiology, 82, 335-341. https://doi.org/10.1016/j.ejrad.2012.10.004 |
[31] | Simkin, P., Rattansingh, A., Liu, K., et al. (2018) Reproducibility of 2 Liver 2-Dimensional Shear Wave Elastographic Techniques in the Fasting and Postprandial States. Journal of Ultrasound in Medicine, 38, 1739-1745.
https://doi.org/10.1002/jum.14862 |
[32] | 王坤, 朱宇莉, 陈凯玲, 包静文, 沈文, 曹佳颖, 董怡, 王文平. 剪切波频散成像鉴别诊断肝肿瘤良恶性的初步应用[J]. 中华超声影像学杂志, 2022, 31(6): 518-524. |