全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

PKMYT1在肿瘤中的研究进展
Advancement of PKMYT1 in Tumor Research

DOI: 10.12677/ACM.2023.1361464, PP. 10463-10467

Keywords: PKMYT1,肿瘤,促癌基因
PKMYT1
, Cancer, Tumor Promoter Gene

Full-Text   Cite this paper   Add to My Lib

Abstract:

PKMYT1基因属于WEE激酶家族的成员,通过在Thr14和Tyr15磷酸化Cdc2来抑制Cdc2活性,PKMYT1基因在胎儿肝脏和其出生后的肝脏之间存在差异性表达,其在细胞中的调控过程及作用已经被广泛研究和报道。近些年来研究表明PKMYT1基因在多种肿瘤如肝癌、肺癌、乳腺癌、食管癌等细胞中呈现高表达,表现为促癌基因的作用,在肿瘤的发生发展中起着重要的作用,本文就PKMYT1目前研究相关进展探讨其与多种肿瘤之间的相关关系。
The PKMYT1 gene belongs to the WEE kinase family and inhibits Cdc2 activity by phosphorylating Cdc2 at Thr14 and Tyr15. There is differential expression of the PKMYT1 gene between fetal liver and postnatal liver, and its regulatory process and role in cells have been widely studied and re-ported. In recent years, studies have shown that PKMYT1 gene is highly expressed in a variety of tumors, such as liver cancer, lung cancer, breast cancer, esophageal cancer and other cells, and it plays an important role in the occurrence and development of tumors. This article discusses the re-lationship between PKMYT1 and various tumors based on the current research progress.

References

[1]  Mueller, P.R., Coleman, T.R., Kumagai, A. and Dunphy, W.G. (1995) Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15. Science, 270, 86-90.
https://doi.org/10.1126/science.270.5233.86
[2]  Schmidt, M., Rohe, A., Platzer, C., Najjar, A., Erdmann, F. and Sippl, W. (2017) Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases. Molecules, 22, 2045.
https://doi.org/10.3390/molecules22122045
[3]  Mueller, P.R., Coleman, T.R., Kumagai, A. and Dunphy, W.G. (1995) Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyro-sine-15. Science, 270, 86-90.
https://doi.org/10.1126/science.270.5233.86
[4]  van Vugt, M.A., Brás, A. and Medema, R.H. (2004) Polo-Like Kinase-1 Controls Recovery from a G2 DNA Damage-Induced Arrest in Mammalian Cells. Molecular Cell, 15, 799-811.
https://doi.org/10.1016/j.molcel.2004.07.015
[5]  Ghelli Luserna di Rorà, A., Cerchione, C., Martinelli, G. and Simonetti, G. (2020) A WEE1 Family Business: Regulation of Mitosis, Cancer Progression, and Therapeutic Target. Journal of Hematology & Oncology., 13, 126.
https://doi.org/10.1186/s13045-020-00959-2
[6]  张琦, 赵鑫, 张春, 等. 过表达PKMYT1促进肿瘤进展, 与食管鳞癌生存率低有关[J]. 癌症管理, 2019(11): 7813-7824.
[7]  孙炽生, 罗敏, 赵海, 等. PKMYT1的过表达表明非小细胞肺癌预后不良, 并通过激活Notch信号通路增强非小细胞肺癌的增殖和肿瘤发生[J]. 欧洲医学药理学(修订版), 2019(23): 4210-4219.
[8]  Liu, Y., Qi, J., Dou, Z., Hu, J., Lu, L., Dai, H., Wang, H. and Yang, W. (2020) Systematic Expression Analysis of WEE Family Kinases Reveals the Importance of PKMYT1 in Breast Carcinogenesis. Cell Proliferation, 53, e12741.
https://doi.org/10.1111/cpr.12741
[9]  Zhang, Q.Y., Chen, X.Q., Liu, X.C. and Wu, D.M. (2020) PKMYT1 Pro-motes Gastric Cancer Cell Proliferation and Apoptosis Resistance. OncoTargets and Therapy, 13, 7747-7757.
https://doi.org/10.2147/OTT.S255746
[10]  赵璇, 王海, 张新恩, 等. PKMYT1通过靶向SIRT3加重卵巢癌的进展[J]. 欧洲医学药理学(修订版), 2020(24): 5259-5266.
[11]  刘林, 吴军, 王淑, 等. PKMYT1通过激活β-连环蛋白/TCF信号传导促进肝细胞癌细胞的生长和运动[J]. 实验细胞研究, 2017(358): 209-216.
[12]  Chayka, O., D’Acunto, C.W., Middleton, O., Arab, M. and Sala, A. (2015) Identification and Pharmacological Inactivation of the MYCN Gene Network as a Therapeutic Strategy for Neuroblastic Tumor Cells. Journal of Biological Chemistry, 290, 2198-212.
https://doi.org/10.1074/jbc.M114.624056
[13]  姚鹏程. 基于TCGA数据的肿瘤预后相关基因数据库的构建[D]: [硕士学位论文]. 成都: 电子科技大学, 2020.
https://doi.org/10.27005/d.cnki.gdzku.2020.004516
[14]  Cancer International Agency for Research on Cancer (2020) Cancer Today 2020.
https://gco.iarc.fr/today/home
[15]  Villanueva, A. (2019) Hepatocellular Carcinoma. The New England Journal of Medicine, 380, 1450-1462.
https://doi.org/10.1056/NEJMra1713263
[16]  Yang, W.S., Zeng, X.F., Liu, Z.N., et al. (2020) Diet and Liver Cancer Risk: A Narrative Review of Epidemiologcal Evidence. British Journal of Nutrition, 124, 330-340.
https://doi.org/10.1017/S0007114520001208
[17]  Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomata-ram, I., Jemal, A. and Bray, F. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249.
https://doi.org/10.3322/caac.21660
[18]  章峥. 基于TCGA数据库肺鳞癌相关基因筛选及CCNB1 mRNA表达的预后分析[D]: [硕士学位论文]. 大理: 大理大学, 2021.
https://doi.org/10.27811/d.cnki.gdixy.2021.000422
[19]  王娜娜, 江楠, 杨晓庆, 房磊, 孙青. 非小细胞肺癌组织起源分子病理分类及其临床意义[J]. 中国肺癌杂志, 2018, 21(7): 530-535.
[20]  Vander Heiden, M.G., Cantley, L.C. and Thompson, C.B. (2009) Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science, 324, 1029-1033.
https://doi.org/10.1126/science.1160809
[21]  Pavlova, N.N. and Thompson, C.B. (2016) The Emerging Hallmarks of Cancer Metabolism. Cell Metabolism, 23, 27-47.
https://doi.org/10.1016/j.cmet.2015.12.006
[22]  李权峰. PKMYT1抑制AKT磷酸化及非小细胞肺癌细胞生长的研究[D]: [硕士学位论文]. 广州: 南方医科大学, 2022.
https://doi.org/10.27003/d.cnki.gojyu.2022.000637
[23]  Trayes, K.P. and Cokenakes, S.E.H. (2021) Breast Cancer Treatment. American Family Physician, 104, 171-178.
[24]  Chen, W., Zheng, R., Baade, P.D., et al. (2020) Cancer Sta-tistics in China, 2015. CA: A Cancer Journal for Clinicians, 66, 115-132.
https://doi.org/10.3322/caac.21338
[25]  Liu, L., Wu, J., Wang, S., et al. (2017) PKMYT1 Promoted the Growth and Motility of Hepatocellular Carcinoma Cells by Activating β-Catenin/TCF Signaling. Experimental Cell Research, 358, 209-216.
https://doi.org/10.1016/j.yexcr.2017.06.014
[26]  Attard, G., Parker, C., Eeles, R.A., et al. (2016) Prostate Cancer. The Lancet, 387, 70-82.
https://doi.org/10.1016/S0140-6736(14)61947-4
[27]  杨进益, 杨明州, 魏伟, 等. 前列腺癌发生发展的流行病学研究[J]. 临床泌尿外科杂志, 2017, 32(9): 721-725.
[28]  王嘉南. 间充质干细胞通过PKMYT1-CCNB1/CCNE1通路影响前列腺癌进展机制研究[D]: [博士学位论文]. 天津: 天津医科大学, 2019.
https://doi.org/10.27366/d.cnki.gtyku.2019.001251
[29]  王茂宇. PKMYT1在膀胱癌中的表达及其功能与机制的研究[D]: [硕士学位论文]. 上海: 中国人民解放军海军军医大学, 2022.
https://doi.org/10.26998/d.cnki.gjuyu.2022.000249
[30]  张庆怡. PKMYT1在食管鳞癌中的表达和机制研究[D]: [硕士学位论文]. 郑州: 郑州大学, 2020.
https://doi.org/10.27466/d.cnki.gzzdu.2020.002778
[31]  Zhang, Q.Y., Chen, X.Q., Liu, X.C. and Wu, D.M. (2020) PKMYT1 Promotes Gastric Cancer Cell Proliferation and Apoptosis Resistance. OncoTargets and Therapy, 13, 7747-7757.
https://doi.org/10.2147/OTT.S255746

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133