%0 Journal Article
%T PKMYT1在肿瘤中的研究进展<br>Advancement of PKMYT1 in Tumor Research
%A 李波涛
%J Advances in Clinical Medicine
%P 10463-10467
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.1361464
%X PKMYT1基因属于WEE激酶家族的成员，通过在Thr14和Tyr15磷酸化Cdc2来抑制Cdc2活性，PKMYT1基因在胎儿肝脏和其出生后的肝脏之间存在差异性表达，其在细胞中的调控过程及作用已经被广泛研究和报道。近些年来研究表明PKMYT1基因在多种肿瘤如肝癌、肺癌、乳腺癌、食管癌等细胞中呈现高表达，表现为促癌基因的作用，在肿瘤的发生发展中起着重要的作用，本文就PKMYT1目前研究相关进展探讨其与多种肿瘤之间的相关关系。<br />
The PKMYT1 gene belongs to the WEE kinase family and inhibits Cdc2 activity by phosphorylating Cdc2 at Thr14 and Tyr15. There is differential expression of the PKMYT1 gene between fetal liver and postnatal liver, and its regulatory process and role in cells have been widely studied and re-ported. In recent years, studies have shown that PKMYT1 gene is highly expressed in a variety of tumors, such as liver cancer, lung cancer, breast cancer, esophageal cancer and other cells, and it plays an important role in the occurrence and development of tumors. This article discusses the re-lationship between PKMYT1 and various tumors based on the current research progress.
%K PKMYT1，肿瘤，促癌基因<br>PKMYT1
%K Cancer
%K Tumor Promoter Gene
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=68225