|
|
中药单体及其有效成分治疗肝癌的研究进展
|
Abstract:
肝癌是最具挑战的恶性癌症之一，它的起源、治疗、预后都存在着诸多未知的风险。然而，通过对中草药的深入探索，已经证实中药具有多重功效，包括：阻断肝癌细胞的生长、诱导肝癌细胞凋亡、抵御外界的侵害、激励机体的免疫系统、调整对化疗的耐受，以及有效地改善肝癌细胞耐药等作用。近年来，随着科学技术的发展，中药已经被证明是一种有效的抗击肝癌的有效手段，它有助于缓解患者的痛苦，缩短病程，延长患者的生存期，以及有效减少西药副作用等功效。本文综述了近年来中药单体及其有效成分在治疗肝癌中的研究进展。
Liver cancer is one of the most challenging malignant cancers. There are many unknown risks in its origin, treatment and prognosis. However, through the in-depth exploration of Chinese herbal medicine, it has been confirmed that Chinese herbal medicine has multiple effects, including: blocking the growth of liver cancer cells, inducing the apoptosis of liver cancer cells, resisting external invasion, stimulating the body’s immune system, adjusting the tolerance to chemotherapy, and effectively improving the drug resistance of liver cancer cells. In recent years, with the development of science and technology, traditional Chinese medicine has been proved to be an effective means of fighting liver cancer. It helps relieve the pain of patients, shorten the course of disease, prolong the survival of patients, and effectively reduce the side effects of western medicine. In this paper, the research progress of TCM monomer and its active components in the treatment of hepatocellular carcinoma in recent years was reviewed.
| [1] | Mattiuzzi, C. and Lippi, G. (2019) Current Cancer Epidemiology. Journal of Epidemiology and Global Health, 9, 217-222. https://doi.org/10.2991/jegh.k.191008.001 |
| [2] | 汪宁, 彭兆快. 腹部超声诊断肝脏肿块及相关疾病的临床应用分析[J]. 医学影像学杂志, 2017, 27(9): 1830-1832. |
| [3] | Zhu, Z., Zhao, Y., Li, J., et al. (2016) Cryptotanshinone, a Novel Tumor Angiogenesis Inhibitor, Destabilizes Tumor Necrosis Factor-α mRNA via Decreasing Nuclear-Cytoplasmictranslocation of RNA-Binding Protein HuR. Molecular Carcinogenesis, 55, 1399-1410. https://doi.org/10.1002/mc.22383 |
| [4] | 赵珍, 李明花. 丹参酮IIA对人肝癌细胞Huh7增殖与凋亡的影响[J]. 中医肿瘤学杂志, 2020, 2(2): 33-38. |
| [5] | Ke, F., Wang, Z., Song, X., et al. (2017) Cryptotanshinone Induces Cell Cycle Arrest and Apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkB Pathways in Cholangiocarcinoma Cells. Drug Design, Development and Therapy, 11, 1753-1766. https://doi.org/10.2147/DDDT.S132488 |
| [6] | 邓凤春, 于占江, 杨钰, 等. 隐丹参酮对人胃癌SGC-7901细胞增殖及血管内皮生长因子mRNA表达的影响[J]. 中国医药导报, 2015, 12(6): 7-10. |
| [7] | 袁雪芳, 王巧晗, 顾薇, 等. 生醋莪术对大鼠原发性肝癌模型的治疗作用研究[J]. 时珍国医国药, 2018, 29(7): 1622-1624. |
| [8] | Sadia Roshan, 柳昀熠, 郑倩, 等. 吉马酮抑制肝癌BEL7402细胞增殖机制初步研究[J]. 时珍国医国药, 2014(12): 2875-2877. |
| [9] | 赵铁建, 傅品悦, 刘露露, 郑洋, 彭岳. 中药莪术几种活性成分对肝脏疾病防治作用的机制[J]. 世界华人消化杂志, 2017, 25(27): 2433-2440. |
| [10] | Huynh, D.L., Sharma, N., Kumar Singh, A., et al. (2017) Anti-Tumor Activity of Wogonin, an Extract from Scutellaria baicalensis, through Regulating Different Signaling Pathways. Chinese Journal of Natural Medicines, 15, 15-40.
https://doi.org/10.1016/S1875-5364(17)30005-5 |
| [11] | 周珍, 刘少平, 周朗, 等. 黄芩素通过PI3K/Akt通路增强三氧化二砷对肝癌细胞的促凋亡作用[J]. 现代肿瘤医学, 2019, 27(10): 1661-1668. |
| [12] | 惠友谊, 薛敬东, 翟延. 基于PI3K/Akt通路探索中医药治疗肝癌机制的研究概述[J]. 环球中医药, 2022, 15(6): 1095-1099. |
| [13] | He, K., Yu, X., Wang, X., et al. (2018) Baicalein and Ly294002 Induces Liver Cancer Cells Apoptosis via Regulating Phoshatidyl Inositol3-Kinase/Akt Signaling Pathway. Journal of Cancer Research and Therapeutics, 14, S519-S525.
https://doi.org/10.4103/0973-1482.235356 |
| [14] | 浦飞飞, 陈凤霞, 夏平. 白花蛇舌草抗肿瘤化学成分和作用机制的研究进展[J]. 癌症进展, 2019, 17(17): 1985-1988, 1996. |
| [15] | Sunwoo, Y.Y., Lee, J.H., Jung, H.Y., et al. (2015) Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine, 2015, Article ID: 501508. https://doi.org/10.1155/2015/501508 |
| [16] | 张彦兵, 朱娇, 肖菊香, 等. 白花蛇舌草总黄酮对TGF-β1诱导肝癌细胞MHCC97-H细胞EMT的逆转作用及其机制[J]. 西安交通大学学报(医学版), 2016, 37(2): 379-306. |
| [17] | 孙超, 吴铭杰, 江泽群, 等. 白化蛇舌草有效成分2-羟基-3-甲基蒽醌通过IL-6/STAT3信号通路诱导肝癌细胞凋亡作用机制[J]. 中华中医药杂志, 2018, 33(12): 5346-5350. |
| [18] | 李梓盟, 张佳彦, 李菲, 付丽娜, 朱志敏, 王刚. 白花蛇舌草抗肿瘤化学成分及药理作用研究进展[J]. 中医药信息, 2021, 38(2): 74-79. https://doi.org/10.19656/j.cnki.1002-2406.210215 |
| [19] | Qian, P., Zhang, Y.W., Zhou, Z.H., et al. (2018) Artesunate Enhances Gammadelta T-Cell-Mediated Antitumor Activity through Augmenting Gammadelta T-Cell Function and Reversing Immune Escape of HepG2 Cells. Immunopharmacology and Immunotoxicology, 40, 107-116. https://doi.org/10.1080/08923973.2017.1386212 |
| [20] | Jing, W., Dong, H., Min, M., et al. (2019) Dependence of Artesunate on Long Noncoding RNA-RP11 to Inhibit Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma. Journal of Cellular Biochemistry, 120, 6026-6034.
https://doi.org/10.1002/jcb.27889 |
| [21] | 王惠国, 王嗣瑶, 韩鑫龙, 李雨桐, 袁立霞, 谭晓梅, 汤庆发, 邢学锋, 陈飞龙, 尹雅蕾, 唐玲. 基于代谢组学分析青蒿琥酯治疗肝癌的作用机制[J]. 中国实验方剂学杂志, 2019, 25(22): 78-85.
https://doi.org/10.13422/j.cnki.syfjx.20191548 |
| [22] | 杨家军, 原明月, 牛野, 陈杨春华, 张会宗, 袁子民. 基于网络药理学和分子对接探讨淫羊藿抗肿瘤作用机制[J]. 药学研究, 2022, 41(5): 292-298+306. https://doi.org/10.13506/j.cnki.jpr.2022.05.003 |
| [23] | Sun, L., Peng, Q., Qu, L., et al. (2015) Anticancer Agent Icaritin Induces Apoptosis through Caspase Dependent Pathways in Human Hepatocellular Carcinoma Cells. Molecular Medicine Reports, 11, 3094-100.
https://doi.org/10.3892/mmr.2014.3007 |
| [24] | Roderfeld, M., Padem, S., Lichtenberger, J., et al. (2020) Schistosoma mansoni Egg Secreted Antigens Activate HCC-Associated Transcription Factors c-Jun and STAT3 in Hamster and Human Hepatocytes. Hepatology, 72, 5324- 5388. https://doi.org/10.1002/hep.30192 |
| [25] | Liu, C.L., Qiu, H., Yu, M.Y., et al. (2017) c-Jun-Mediated β-1,3-N-Acetylglucosaminyltransferase 8 Expression: A Novel Mechanism Regulating the Invasion and Metastasis of Colorectal Carcinoma Cells. Oncology Letters, 14, 3722- 3728. https://doi.org/10.3892/ol.2017.6624 |
| [26] | Lee, K.Y., Park, J.A., Chung, E., et al. (1996) Ginsenoside-Rh 2 Blocks the Cell Cycle of SK-Hep-1 Cells at the G1/S Boundary by Selectively Inducing the Protein Expression of p27 kip1. Cancer Letters, 110, 193-200.
https://doi.org/10.1016/S0304-3835(96)04502-8 |
| [27] | 张奉海, 张瑞荣, 陈淑娟, 王全红, 于永兰. 人参皂苷Rh2联合紫杉醇治疗人肝癌细胞HepG2和移植瘤小鼠的效果[J]. 中国民康医学, 2021, 33(9): 1-4+10. |
| [28] | 王娜, 刘刚, 刘欢, 等. 人参皂苷下调IL-1受体相关激酶1基因表达抑制肝癌细胞增殖及促进其凋亡作用及机制[J]. 现代肿瘤医学, 2017, 25(8): 1183-1187. |
| [29] | 颜春鲁, 骆亚莉, 安方玉, 等. 黄芪总皂苷联合顺铂对H_(22)荷瘤小鼠STAT3介导的炎症信号通路的抑制作用[J]. 中国生物化学与分子生物学报, 2020, 36(11): 1359-1366. |
| [30] | 吕君, 朱鹏飞, 刘艳民, 等. 黄芪多糖通过Wnt/β-catenin信号通路促进肝癌细胞凋亡研究[J]. 中草药, 2018, 49(21): 5155-5160. |
| [31] | 张秀云, 陈建业, 杨映雪, 等. 黄芪总黄酮对肝癌HepG-2细胞凋亡的诱作用[J]. 中华中 医药学刊, 2013, 31(6): 1320-1322. |
| [32] | Zheng, Y.J., Ren, W.Y., Zhang, L.N., et al. (2020) A Review of the Pharmacological Action of Astragalus Polysaccharide. Frontiers in Pharmacology, 11, Article No. 349. https://doi.org/10.3389/fphar.2020.00349 |
| [33] | Wang, Y.L., Horng, C.T., Hsieh, M.T., et al. (2019) Autophagy and Apoptotic Machinery Caused by Polygonum cuspidatum Extract in Cisplatin? Resistant Human Oral Cancer CAR Cells. Oncology Reports, 41, 2549-2557.
https://doi.org/10.3892/or.2019.6985 |
| [34] | Pan, X., Wang, C., Li, Y., et al. (2018) Protective Autophagy Induced by Physcion Suppresses Hepatocellular Carcinoma Cell Metastasis by In-Activating the JAK2/STAT3 Axis. Life Sciences, 214, 124-135.
https://doi.org/10.1016/j.lfs.2018.10.064 |
| [35] | Dai, H., Li, M., Yang, W., et al. (2020) Resveratrol Inhibits the Malignant Progression of Hepatocellular Carcinoma via MARCH1-Induced Regulation of PTEN/AKT Signaling. Aging (Albany NY), 12, 11717-11731.
https://doi.org/10.18632/aging.103338 |
| [36] | 韦艳, 陆艳玲, 王荣荣, 等. 槲皮素对缺氧人肝癌细胞HepG2增殖及HIF-1α？VEGF的影响[J]. 武警医学, 2018, 29(2): 134-137. |
| [37] | Zhang, S.H., Yan, Z., Yan, Z., et al. (2017) Matrine Induces Apoptosis in Human Acute Myeloid Leukemia Cells via the Mitochondrial Pathway and Akt Inactivation. PLOS ONE, 7, e46853. https://doi.org/10.1371/journal.pone.0046853 |
| [38] | Zhang, J., Gao, Y., Han, H., et al. (2019) Matrine Suppresses Lung Metastasis of Human Hepatocellular Carcinoma by Directly Targeting Matrix Met Alloproteinase-9. Biochemical and Biophysical Research Communications, 515, 57-63.
https://doi.org/10.1016/j.bbrc.2019.04.063 |
| [39] | 郭浩, 周淑妮, 冉瑞智. 苦参碱调控肝癌细胞HepG2自噬作用机制研究[J]. 中国药业, 2019, 28(6): 14-17. |
| [40] | 谢小青, 杨晓娟, 卢利霞, 等. 苦参碱通过P38MAPK和JNK信号通路抑制肝癌细胞增殖的分子机制研究[J]. 兰州大学学报(医学版), 2022, 48(1): 38-43. https://doi.org/10.13885/j.issn.1000-2812.2022.01.009 |
