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新型生物标志物在开颅术后颅内感染诊断中的研究进展
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Abstract:
神经外科术后细菌性脑膜炎(post-neurosurgical bacterial meningitis, PNBM)是开颅术后最常见的并发症，可导致显著的发病率和死亡率；虽然无菌技术越发成熟，但细菌性脑膜炎仍然是神经外科手术过程中不可避免的障碍，且传统生物标志物、临床症状及影像学检查对于细菌性及无菌性炎症鉴别受限，因此本文就新型生物标志物以及脑脊液基因检测在PNBM早期诊断的研究进展进行综述。
Post-neurosurgical bacterial meningitis (PNBM) is the most common complication after craniotomy, which can lead to significant morbidity and mortality. Although aseptic technology is becoming more mature, bacterial meningitis is still an unavoidable obstacle in neurosurgery, and traditional biomarkers, clinical symptoms and imaging examinations are limited in the differentiation of bac-terial and aseptic inflammation, so this article reviews the research progress of novel biomarkers in the early diagnosis of PNBM.
| [1] | Wall, E.C., Chan, J.M., Gil, E. and Heyderman, R.S. (2021) Acute Bacterial Meningitis. Current Opinion in Neurology, 34, 386-395. https://doi.org/10.1097/WCO.0000000000000934 |
| [2] | Suthar, R. and Sankhyan, N. (2019) Bacterial Infections of the Central Nervous System. Indian Journal of Pediatrics, 86, 60-69. https://doi.org/10.1007/s12098-017-2477-z |
| [3] | Zhan, R., Zhu, Y., Shen, Y., Shen, J., Tong, Y., Yu, H. and Wen, L. (2014) Post-Operative Central Nervous System Infections after Cranial Surgery in China: Incidence, Causative Agents, and Risk Factors in 1,470 Patients. European Journal of Clinical Microbiology & Infectious Diseases, 33, 861-866. https://doi.org/10.1007/s10096-013-2026-2 |
| [4] | Zhang, Z., Song, Y., Kang, J., Duan, S., Li, Q., Feng, F. and Duan, J. (2021) Epidemiology of Patients with Central Nervous System Infections, Mainly Neurosurgical Patients: A Retrospective Study from 2012 to 2019 in a Teaching Hospital in China. BMC Infectious Diseases, 21, Article No. 826. https://doi.org/10.1186/s12879-021-06561-2 |
| [5] | Zhai, T., Fu, Z.L., Qiu, Y.B., Chen, Q., Luo, D. and Chen, K. (2020) Application of Combined Cerebrospinal Fluid Physicochemical Parameters to Detect Intracranial Infection in Neurosurgery Patients. BMC Neurology, 20, Article No. 213. https://doi.org/10.1186/s12883-020-01781-6 |
| [6] | 中国医师协会神经外科医师分会神经重症专家委员会, 北京医学会神经外科学分会神经外科危重症学组. 神经外科中枢神经系统感染诊治中国专家共识(2021版) [J]. 中华神经外科杂志, 2021, 37(1): 2-15.
https://doi.org/10.3760/cma.j.cn112050-20200831-00480 |
| [7] | Le Govic, Y., Demey, B., Cassereau, J., Bahn, Y.S. and Papon, N. (2022) Pathogens Infecting the Central Nervous System. PLOS Pathogens, 18, e1010234. https://doi.org/10.1371/journal.ppat.1010234 |
| [8] | de Morais, S.D., Kak, G., Menousek, J.P. and Kielian, T. (2021) Immunopathogenesis of Craniotomy Infection and Niche-Specific Immune Responses to Biofilm. Frontiers in Immu-nology, 12, Article ID: 625467.
https://doi.org/10.3389/fimmu.2021.625467 |
| [9] | Cherian, A., Baheti, N.N., Easwar, H.V., Nair, D.S. and Iype, T. (2012) Recurrent Meningitis due to Epidermoid. Journal of Pediatric Neurosciences, 7, 47-48. https://doi.org/10.4103/1817-1745.97624 |
| [10] | Zhao, Z., Nelson, A.R., Betsholtz, C. and Zlokovic, B.V. (2015) Establishment and Dysfunction of the Blood-Brain Barrier. Cell, 163, 1064-1078. https://doi.org/10.1016/j.cell.2015.10.067 |
| [11] | Maskin, L.P., Capparelli, F., Mora, A., Hlavnicka, A., Orellana, N., Díaz, M.F., Wainsztein, N. and Del Castillo, M. (2013) Cerebrospinal Fluid Lactate in Post-Neurosurgical Bacterial Meningitis Diagnosis. Clinical Neurology and Neurosurgery, 115, 1820-1825. https://doi.org/10.1016/j.clineuro.2013.05.034 |
| [12] | Kim, Y.J., Moon, K.S., Kim, S.K., Kang, S.J., Lee, K.H., Jang, W.Y., Jung, T.Y., Kim, I.Y. and Jung, S. (2014) The Difference in Diffusion-Weighted Imaging with Apparent Diffu-sion Coefficient between Spontaneous and Postoperative Intracranial Infection. British Journal of Neurosurgery, 28, 765-770.
https://doi.org/10.3109/02688697.2014.931349 |
| [13] | Casado-Flores, J., Blanco-Quirós, A., Nieto, M., Asensio, J. and Fernández, C. (2006) Prognostic Utility of the Semi-Quantitative Procalcitonin Test, Neutrophil Count and C-Reactive Protein in Meningococcal Infection in Children. European Journal of Pediatrics, 165, 26-29. https://doi.org/10.1007/s00431-005-1761-5 |
| [14] | Foushee, J.A., Hope, N.H. and Grace, E.E. (2012) Applying Bi-omarkers to Clinical Practice: A Guide for Utilizing Procalcitonin Assays. Journal of Antimicrobial Chemotherapy, 67, 2560-2569. https://doi.org/10.1093/jac/dks265 |
| [15] | Shimetani, N., Shimetani, K. and Mori, M. (2001) Levels of Three Inflammation Markers, C-Reactive Protein, Serum Amyloid A Protein and Procalcitonin, in the Serum and Cere-brospinal Fluid of Patients with Meningitis. Scandinavian Journal of Clinical and Laboratory Investigation, 61, 567-574. https://doi.org/10.1080/003655101753218337 |
| [16] | Jereb, M., Muzlovic, I., Hojker, S. and Strle, F. (2001) Predic-tive Value of Serum and Cerebrospinal Fluid Procalcitonin Levels for the Diagnosis of Bacterial Meningitis. Infection, 29, 209-212.
https://doi.org/10.1007/s15010-001-1165-z |
| [17] | Karzai, W., Oberhoffer, M., Meier-Hellmann, A. and Reinhart, K. (1997) Procalcitonin—A New Indicator of the Systemic Response to Severe Infections. Infection, 25, 329-334. https://doi.org/10.1007/BF01740811 |
| [18] | Müller, B., White, J.C., Nylén, E.S., Snider, R.H., Becker, K.L. and Habener, J.F. (2001) Ubiquitous Expression of the Calcitonin-I Gene in Multiple Tissues in Response to Sepsis. The Journal of Clinical Endocrinology & Metabolism, 86, 396-404. https://doi.org/10.1210/jc.86.1.396 |
| [19] | Viallon, A., Desseigne, N., Marjollet, O., Birynczyk, A., Belin, M., Guyomarch, S., Borg, J., Pozetto, B., Bertrand, J.C. and Zeni, F. (2011) Meningitis in Adult Patients with a Negative Direct Cerebrospinal Fluid Examination: Value of Cytochemical Markers for Differential Diagnosis. Critical Care, 15, R136. https://doi.org/10.1186/cc10254 |
| [20] | Yu, Y. and Li, H.J. (2017) Diagnostic and Prognostic Value of Procalcitonin for Early Intracranial Infection after Craniotomy. Brazilian Journal of Medical and Biological Research, 50, e6021.
https://doi.org/10.1590/1414-431x20176021 |
| [21] | Wang, H. (2020) Higher Procalcitonin Level in Cerebrospinal Fluid than in Serum Is a Feasible Indicator for Diagnosis of Intracranial Infection. Surgical Infections (Larchmt), 21, 704-708. https://doi.org/10.1089/sur.2019.194 |
| [22] | Zhu, L., Dong, L., Li, Y., Lu, G., Zhang, H., Wang, X., Liu, X., Teng, Z., Xia, B. and Zhang, P. (2019) The Diagnostic and Antibiotic Reference Values of Procalcitonin for Intracranial Infection after Craniotomy. World Neurosurgery, 126, e1-e7. https://doi.org/10.1016/j.wneu.2018.10.241 |
| [23] | Yang, Y., Liu, G., He, Q., Shen, J., Xu, L., Zhu, P. and Zhao, M. (2019) A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction. Journal of Immu-nology Research, 2019, Article ID: 7515346.
https://doi.org/10.1155/2019/7515346 |
| [24] | Kandil, M., Khalil, G., El-Attar, E., Shehata, G. and Hassan, S. (2018) Accuracy of Heparin Binding Protein: As a New Marker in Prediction of Acute Bacterial Meningitis. Brazilian Journal of Microbiology, 49, 213-219.
https://doi.org/10.1016/j.bjm.2018.05.007 |
| [25] | Kong, Y., Ye, Y., Ma, J. and Shi, G. (2022) Accuracy of Hepa-rin-Binding Protein for the Diagnosis of Nosocomial Meningitis and Ventriculitis. Critical Care, 26, Article No. 56. https://doi.org/10.1186/s13054-022-03929-x |
| [26] | Zhang, Y., Zhou, Y., Hou, M. and Zhang, S. (2022) Analysis of Cerebrospinal Fluid Routine Biochemical Level, Pathogenic Bacteria Distribution, and Risk Factors in Patients with Sec-ondary Intracranial Infection after Brain Tumor Surgery. Evidence-Based Complementary and Alternative Medicine, 2022, Article ID: 7716205.
https://doi.org/10.1155/2022/7716205 |
| [27] | Cunha, B.A. (2006) Distinguishing Bacterial from Viral Meningitis: The Critical Importance of the CSF Lactic Acid Levels. Intensive Care Medicine, 32, 1272-1273. https://doi.org/10.1007/s00134-006-0210-x |
| [28] | Xiao, X., Zhang, Y., Zhang, L., Kang, P. and Ji, N. (2016) The Diagnostic Value of Cerebrospinal Fluid Lactate for Post-Neurosurgical Bacterial Meningitis: A Meta-Analysis. BMC Infectious Diseases, 16, Article No. 483.
https://doi.org/10.1186/s12879-016-1818-2 |
| [29] | Kul, G., Sencan, I., Kul, H., Korkmaz, N. and Altunay, E. (2020) The Role of Cerebrospinal Fluid Biomarkers in the Diagnosis of Post-Neurosurgical Meningitis. Turkish Neurosurgery, 30, 513-519.
https://doi.org/10.5137/1019-5149.JTN.25175-18.2 |
| [30] | Venkatesh, B., Morgan, T.J., Boots, R.J., Hall, J. and Siebert, D. (2003) Interpreting CSF Lactic Acidosis: Effect of Erythrocytes and Air Exposure. Critical Care and Resus-citation, 5, 177-181. |
| [31] | Liu, Q., Gao, Y., Zhang, B., Sun, F., Yang, Q., Liu, Y., Wu, J., Chen, K., Weng, X., Zhang, W., Huang, R. and Shao, L. (2020) Cytokine Profiles in Cerebrospinal Fluid of Patients with Meningitis at a Tertiary General Hospital in China. Journal of Microbiology, Immunology and Infection, 53, 216-224. https://doi.org/10.1016/j.jmii.2018.08.019 |
| [32] | Cuff, S.M., Merola, J.P., Twohig, J.P., Eberl, M. and Gray, W.P. (2020) Toll-Like Receptor Linked Cytokine Profiles in Cerebrospinal Fluid Discriminate Neurological Infection from Sterile Inflammation. Brain Communications, 2, fcaa218.
https://doi.org/10.1093/braincomms/fcaa218 |
| [33] | 吴蕾, 张少兰, 黄华玮, 石广志. 宏基因组二代测序对神外术后颅内细菌感染病原菌的诊断效能[J]. 中华医学杂志, 2022, 102(29): 2272-2277. https://doi.org/10.3760/cma.j.cn112137-20211128-02659 |
| [34] | Kanaujia, R., Biswal, M., Angrup, A. and Ray, P. (2022) Diagnostic Accuracy of the Metagenomic Next-Generation Sequencing (mNGS) for Detection of Bacterial Me-ningoencephalitis: A Systematic Review and Meta-Analysis. European Journal of Clinical Microbiology & Infectious Diseases, 41, 881-891.
https://doi.org/10.1007/s10096-022-04445-0 |
| [35] | Wang, J., Ye, J., Yang, L., Chen, X., Fang, H., Liu, Z., Xia, G., Zhang, Y. and Zhang, Z. (2022) Inconsistency Analysis between Metagenomic Next-Generation Sequencing Results of Cerebrospinal Fluid and Clinical Diagnosis with Suspected Central Nervous System Infection. BMC Infectious Diseases, 22, Article No. 764.
https://doi.org/10.1186/s12879-022-07729-0 |
